Synthesis and In Vitro Anticancer Activity of Novel 6,8,9-Trisubstituted Purine Analogs

Polat, Muhammed Fatih
Tunçbilek, Meral
Durmaz, İrem
Atalay, Rengül


Synthesis and in vitro studies of selenophene containing BODIPY derivatives as mitochondria targeted photodynamic therapy agents
Karaman, Osman; Günbaş, Emrullah Görkem; Department of Chemistry (2019)
Weakly coordinating anions are extremely versatile species for capturing and characterizing cationic intermediates. Among these anions, carboranes and some boranes are known to be the most weakly coordinating anions. In this thesis, the carboranes and boranes were synthesized in order to capture and characterize unusual carbocations. B11H14-was synthesized from NaBH4. Undecaborate was converted to B10H14 by oxidation and extrusion of one boron vertex. The B10H14 was successfully converted to ortho-carborane...
Synthesis and Cytoxicity of a TAT Peptide Doxorubicin Conjugate for Breast Cancer Treatment
Gülseren Petek, Şen; Yalçın Azarkan, Serap; Gündüz, Ufuk (JSciMed Central, 2015-01-01)
The TAT peptide is a drug delivery tools which has been efficiently proven to deliver drugs, peptides and nucleic acids. A specific sequence of HIV1 protein transduction domain TAT was evaluated for its ability to carry Doxorubicin (Dox) into drug resistant MCF-7 tumor cells. TAT was conjugated to Dox via the formation of a disulfide bond. In this study, we developed an optimal formulation for the conjugation of Dox by this delivery system for tumor treatment. The in vitro study showed that DoxTAT peptide c...
Synthesis and Structural Characterization of Some 5 6 Substituted 2 hydroxymethyl benzimidazole derivatives and their platinum II complexes and determination of their in vitro antitumor activity by Rec Assay Test
İzgü, Kadri Fatih; Gümüş, Fatma; Algül, Öztekin (1996-01-01)
Synthesis and cross-linking of photoactivateable biotinylated ligands of G protein-coupled receptors
Sargsyan, Hasmik; Son, Çağdaş Devrim; Becker, Jeffrey M.; Naider, Fred (2004-01-01)
Synthesis and enhanced photocatalytic activity of nitrogen-doped triphasic TiO2 nanoparticles
Erdogan, Nursev; Bouziani, Asmae; PARK, JONGEE; Micusik, Matej; Kim, Soo Young; Majkova, Eva; Omastova, Maria; Öztürk, Abdullah (Elsevier BV, 2019-05-15)
TiO2 nanoparticles of the single anatase phase, binary anatase-brookite phases, and ternary anatase-brookite-rutile phases were synthesized using an HNO3-catalyzed hydrothermal process. The types and amounts of phases varied depending on the hydrothermal synthesis conditions. The results revealed that N dissolves in different amounts and chemical states, depending on the phases present and their proportions in the nano particles. Brookite and rutile nanoparticles oriented through one direction were found to...
Citation Formats
M. F. Polat, M. Tunçbilek, İ. Durmaz, and R. Atalay, “Synthesis and In Vitro Anticancer Activity of Novel 6,8,9-Trisubstituted Purine Analogs,” 2017, Accessed: 00, 2021. [Online]. Available: