Numerical investigation of living cells under ultrasonic excitation in microfluidic devices

Download

12626005.pdf

Date

2020-12-28

Author

Açıkgöz, Hande Nur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

214
views

162
downloads

Acoustophoretic microfluidic applications are an essential part of Lab-on-a-chip systems. Studies about acoustophoretic particle manipulation are available in the literature. However, conventional analytical methods fall short of including many factors affecting acoustophoretic manipulation of biological samples when applied to biological systems. Therefore, numerical methods become useful tools to investigate the phenomena to a larger extent. This thesis aims to analyze the factors of particle geometry, sample concentration, and the channel wall effect. To go beyond the isolated particle assumption, methods presented take the particle's acoustic interaction with other particles and channel walls into consideration while putting no restriction on particle shape. The acoustic simulation model, created for this purpose, is integrated into a code for hydrodynamic calculations to obtain particle trajectories under different circumstances. The coupled method renders acoustophoretic particle manipulation simulations in microfluidic channels and includes both acoustic and hydrodynamic interactions

Subject Keywords

Cell, Numerical Simulations, Acoustic Radiation Force

URI

https://hdl.handle.net/11511/89701

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Computation and analysis of spectra of large undirected networks Erdem, Özge; Karasözen, Bülent; Jost, Jürgen; Department of Scientific Computing (2010) Many interacting complex systems in biology, in physics, in technology and social systems, can be represented in a form of large networks. These large networks are mathematically represented by graphs. A graph is represented usually by the adjacency or the Laplacian matrix. Important features of the underlying structure and dynamics of them can be extracted from the analysis of the spectrum of the graphs. Spectral analysis of the so called normalized Laplacian of large networks became popular in the recent ...
A tunable carbon nanotube electromechanical oscillator Sazonova, V; Yaish, Y; Toffoli, Hande; Roundy, D; Arias, TA; McEuen, PL (2004-09-01) Nanoelectromechanical systems (NEMS) hold promise for a number of scientific and technological applications. In particular, NEMS oscillators have been proposed for use in ultrasensitive mass detection(1,2), radio-frequency signal processing(3,4), and as a model system for exploring quantum phenomena in macroscopic systems(5,6). Perhaps the ultimate material for these applications is a carbon nanotube. They are the stiffest material known, have low density, ultrasmall cross-sections and can be defect-free. E...
Optical Response of Lorentzian Nanoshells in the Quasistatic Limit Gulen, Demet (American Chemical Society (ACS), 2013-09-26) Recently, plexcitonic systems consisting of a plasmonic nanoshell or a core covered by an excitonic shell are engineered. Such systems hold promise for tunable nano-photonic devices for imaging, chemical sensing, and resonance energy transfer. Their plasmonic response is grasped well, while understanding of their excitonic response remains to be improved. To this end, we have developed a methodology in which the functionalities of the dispersive properties of the spherical shell and the nanoenvironment in t...
Analysis and Control of Complex Flows in U-Bends using Computational Fluid Dynamics Guden, Yigitcan; Yavuz, Mehmet Metin (2014-08-07) Analysis and control of flow structure in U-bends are crucial since U-bends are used in many different engineering applications. As a flow parameter in U-bends, the ratio of inertial and centrifugal forces to viscous forces is called as Dean number. The increase of Dean number destabilizes the flow and leads to a three-dimensional flow consisting of stream wise parallel counter-rotating vortices (Dean vortices) stacked along the curved wall. Due to the curvature in U-bends, the flow development involves com...
Implementation of mesh generation algorithms Yıldız, Özgür; Yüksel, Önder; Kuzuoğlu, Mustafa; Department of Electrical and Electronics Engineering (2001) In this thesis, three mesh generation software packages have been developed and implemented. The first two were based on structured mesh generation algorithms and used to solve structured surface and volume mesh generation problems of three-dimensional domains. Structured mesh generation algorithms were based on the concept of isoparametric coordinates. In structured surface mesh generation software, quadrilateral mesh elements were generated for complex three-dimensional surfaces and these elements w...

Citation Formats

H. N. Açıkgöz, “Numerical investigation of living cells under ultrasonic excitation in microfluidic devices,” M.S. - Master of Science, Middle East Technical University, 2020.