Numerical investigation of living cells under ultrasonic excitation in microfluidic devices

Açıkgöz, Hande Nur
Acoustophoretic microfluidic applications are an essential part of Lab-on-a-chip systems. Studies about acoustophoretic particle manipulation are available in the literature. However, conventional analytical methods fall short of including many factors affecting acoustophoretic manipulation of biological samples when applied to biological systems. Therefore, numerical methods become useful tools to investigate the phenomena to a larger extent. This thesis aims to analyze the factors of particle geometry, sample concentration, and the channel wall effect. To go beyond the isolated particle assumption, methods presented take the particle's acoustic interaction with other particles and channel walls into consideration while putting no restriction on particle shape. The acoustic simulation model, created for this purpose, is integrated into a code for hydrodynamic calculations to obtain particle trajectories under different circumstances. The coupled method renders acoustophoretic particle manipulation simulations in microfluidic channels and includes both acoustic and hydrodynamic interactions


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Citation Formats
H. N. Açıkgöz, “Numerical investigation of living cells under ultrasonic excitation in microfluidic devices,” M.S. - Master of Science, Middle East Technical University, 2020.