Induction of Protease-Resistant Prion Protein and alpha-synuclein Aggregation by Human alpha-synuclein Fibrils in Cultured Cells

Tran, Hoang N.
Narkiewicz, Joanna
Nowodworska, Arletta
Bek, Alpan
Legname, Giuseppe


Induction of apoptosis and cell cycle arrest on U266 multiple myeloma cell line by prochlorperazine
Hüsnügil, Hepşen Hazal; Özen, Can; Banerjee, Sreeparna; Department of Biochemistry (2016)
Multiple myeloma (MM) is a plasma cell neoplasm accounting for 1% of all malignancies and 13% of hematological malignancies. Despite the introduction of potent anticancer agents, MM remains as an incurable disease. High frequency of relapses and acquisition of resistance to current chemotherapy create a need for the development of novel agents for MM treatment. Prochlorperazine (PCP) is an FDA-approved phenothiazine drug, mainly used for the treatment of chemotherapy-associated nausea and vomiting. In addit...
Induction of embryogenic tissue and maturation of somatic embryos in Pinus brutia TEN
Yildirim, Tolga; Kaya, Zeki; Isik, Kani (Springer Science and Business Media LLC, 2006-10-01)
Embryogenic tissues (ET) of Turkish red pine (Pinus brutia TEN) were initiated from immature precotyledonary zygotic embryos sampled from 15 different plus trees. Seven collections were made weekly from June 10 to July 22, 2003. DCR basal medium supplemented with 13.6 mu M 2,4-dichlorophenoxyacetic acid (2,4-D) and 2.2 mu M benzylaminopurine (BAP) was used for initiation and maintenance of ET. Overall initiation frequency of ET in the study was 11.6%, initiation rates ranging between 4.7% and 24.1% per tree...
Induction of embryogenic tissue and development of somatic embryos in pinus brutia ten
Yıldırım, Tolga; Kaya, Zeki; Department of Biology (2005)
Conifer species are subjected to major time constraints in tree improvement because of their long regeneration cycle and large sizes. However, integration of developing biotechnologies could significantly reduce this time limitation in tree breeding programs. In this regard, somatic embryogenesis (SE) offers a great potential in commercially important Turkish red pine (Pinus brutia TEN.) for rapid production of larger number of clones as well as capture of greater genetic gains. In this study, seven collect...
Induction of embryogenic tissue from immature zygotic embryos in Pinus nigra J.F. Arnold subsp. nigra var. caramanica (Loudon) Businsky
Özkurt, Zeynep; Yildirim, Tolga; Önde, Sertaç; Kaya, Zeki (2008-06-12)
Embryogenic cultures (EC) of Anatolian black pine (Pinus nigra J.F.Arnold subsp. nigra var. caramanica (Loudon) Businsky) were initiated from immature pre-cotyledonary zygotic embryos sampled weekly from 16 different trees in 2 consecutive years. Douglas-fir cotyledon revised (DCR) medium supplemented with 13.6 μM of 2,4-D and 2.2 μM of BAP was used for initiation and maintenance of EC. Overall initiation frequencies of EC in the study were 0.92% in 2004 and 1.96% in 2005: tree values ranged from 0.0% to 7....
Induction of N-nitrosodimethylamine metabolism in liver and lung by in vivo pyridine treatments of rabbits
Arinc, E; Adalı, Orhan; Gencler-Ozkan, AM (2000-08-01)
N-Nitrosodimethylamine is a procarcinogen that is activated by cytochrome P450 dependent N-nitrosodimethylamine N-demethylase to labile alpha-carbon hydroxylated products further resulting in active methylating agents. In vivo intraperitoneal administration of pyridine to rabbits significantly increased N-nitrosodimethylamine N-demethylase activity by 6.9- and 5.2-fold in liver and lung microsomes, respectively. Although, p-nitrophenol hydroxylase and aniline 4-hydroxylase activities were markedly enhanced ...
Citation Formats
H. N. Tran, J. Narkiewicz, A. Nowodworska, A. Bek, and G. Legname, “Induction of Protease-Resistant Prion Protein and alpha-synuclein Aggregation by Human alpha-synuclein Fibrils in Cultured Cells,” PRION, vol. 5, pp. 112–112, 2011, Accessed: 00, 2021. [Online]. Available: