Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication

Yurtman, Erinç
Özer, Onur
Yüncü, Eren
Dağtaş, Nihan Dilşad
Koptekin, Dilek
Çakan, Yasin Gökhan
Özkan, Mustafa
Akbaba, Ali
Kaptan, Damla
Atağ, Gözde
Vural, Kıvılcım Başak
Gündem, Can Yümni
Martin, Louise
Kılınç, Gülşah Merve
Ghalichi, Ayshin
Açan, Sinan Can
Yaka, Reyhan
Sağlıcan, Ekin
Lagerholm, Vendela Kempe
Krzewińska, Maja
Günther, Torsten
Miranda, Pedro Morell
Pişkin, Evangelia
Şevketoğlu, Müge
Bilgin, C. Can
Atakuman, Çiğdem
Erdal, Yılmaz Selim
Sürer, Elif
Altınışık, N. Ezgi
Lenstra, Johannes A.
Yorulmaz, Sevgi
Abazari, Mohammad Foad
Hoseinzadeh, Javad
Baird, Douglas
Bıçakçı, Erhan
Çevik, Özlem
Gerritsen, Fokke
Özbal, Rana
Götherström, Anders
Somel, Mehmet
Togan, Inci
Özer, Füsun
Sheep were among the first domesticated animals, but their demographic history is little understood. Here we analyzed nuclear polymorphism and mitochondrial data (mtDNA) from ancient central and west Anatolian sheep dating from Epipaleolithic to late Neolithic, comparatively with modern-day breeds and central Asian Neolithic/Bronze Age sheep (OBI). Analyzing ancient nuclear data, we found that Anatolian Neolithic sheep (ANS) are genetically closest to present-day European breeds relative to Asian breeds, a conclusion supported by mtDNA haplogroup frequencies. In contrast, OBI showed higher genetic affinity to present-day Asian breeds. These results suggest that the east-west genetic structure observed in present-day breeds had already emerged by 6000 BCE, hinting at multiple sheep domestication episodes or early wild introgression in southwest Asia. Furthermore, we found that ANS are genetically distinct from all modern breeds. Our results suggest that European and Anatolian domestic sheep gene pools have been strongly remolded since the Neolithic.


Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication
Pişkin, Evangelia; Somel, Mehmet; Özer, Füsün; Dağtaş, Dilsad; Köptekin, D; Erdal, Yılmaz Selim; Çevik, Özlem; Gündem, Can Yümni; Yaka, Reyhan; Akbaba, Ali; Yüncü, E; Çakan, Y G (2021-09-01)
Sheep was among the first domesticated animals, but its demographic history is little understood. Here we present combined analyses of mitochondrial and nuclear polymorphism data from ancient central and west Anatolian sheep dating to the Late Glacial and early Holocene. We observe loss of mitochondrial haplotype diversity around 7500 BCE during the early Neolithic, consistent with a domestication-related bottleneck. Post-7000 BCE, mitochondrial haplogroup diversity increases, compatible with admixture from...
Archaeogenomic analysis of genetic and cultural interactions in Neolithic Anatolian societies (NEOGENE)
Somel, Mehmet; Atakuman, Çiğdem; Sürer, Elif(2023)
The Neolithic Transition in the Near East (c.10,000-6,000 BC) was a period of singular sociocultural change, when societies adopted sedentary life and agriculture for the first time in human history. This project will jointly use genomic and quantitative cultural data to explore Transition societies’ organisation, interactions, and their social and demographic evolution in time. (1) We will start by dissecting social structures within Neolithic communities in Anatolia, studying the role of kinship, postmari...
Evolutionary relationship among three native and two crossbreed sheep breeds of Turkey: preliminary results
Soysal, MI; Koban, E; Ozkan, E; Altunok, V; Bulut, Z; Nizamlioglu, M; Togan, İnci Zehra (2005-05-01)
The Turkish native sheep breeds, possibly being the neighbours of the earliest domesticated sheep populations, might be harbouring important genetic characteristics to be employed in the future for the improvement of sheep breeds. In order to design a conservation strategy, their genetic diversities must be determined. In the present study, based on three microsatellite loci, the genetic diversity of the Kivircik, Awassi, Akkaraman breeds (native) of Turkey as well as two of their crossbreeds Turkgeldi and ...
Mitochondrial DNA Diversity of Modern, Ancient and Wild Sheep (Ovis gmelinii anatolica) from Turkey: New Insights on the Evolutionary History of Sheep
Demirci, Sevgin; Bastanlar, Evren Koban; Dagtas, Nihan Dilsad; Pişkin, Evangelia; ENGİN, ATİLLA; Ozer, Fusun; Yuncu, Eren; Dogan, Sukru Anil; TOGAN, İNCİ ZEHRA (2013-12-11)
In the present study, to contribute to the understanding of the evolutionary history of sheep, the mitochondrial (mt) DNA polymorphisms occurring in modern Turkish native domestic (n = 628), modern wild (Ovis gmelinii anatolica) (n = 30) and ancient domestic sheep from Oylum Hoyuk in Kilis (n = 33) were examined comparatively with the accumulated data in the literature. The lengths (75 bp/76 bp) of the second and subsequent repeat units of the mtDNA control region (CR) sequences differentiated the five hapl...
Archaeogenomic analysis of population genetic relationships and kinship patterns in the sedentary societies from neolithic anatolia
Yaka, Reyhan; Somel, Mehmet; Özer, Füsun; Department of Molecular Biology and Genetics (2020-1-12)
The Neolithic way of life first emerged in the Fertile Crescent (c.10thand early 9thmillennium cal BCE) and quickly spread to neighbouring regionssuch as Central Anatoliaand Cyprus,and eventually further westwards. This transition involved to fundamental changes in human lifestyle,with the first emergence of villages during the early Neolithicandthe later the growing reliance on farming and herdingduring the late Neolithic periods. Changes in the social organization of sedentary communi...
Citation Formats
E. Yurtman et al., “Archaeogenetic analysis of Neolithic sheep from Anatolia suggests a complex demographic history since domestication,” COMMUNICATIONS BIOLOGY, no. 4, pp. 1–11, 2021, Accessed: 00, 2021. [Online]. Available: