Development and Implementation of Ultrafast Ultrasound Imaging

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2022-1-25

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Berberoğlu, Eda Begüm

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Ultrasound imaging provides noninvasive, safe and real-time visualization for soft tissues. Ultrasound contrast agents have been used to improve imaging performance by enhancing echo signals for diagnostic and therapeutic purposes. Plane wave imaging started a new era on ultrasound imaging due to providing high frame rate acquisitions, which enabled ultrasound imaging well below the diffraction limit. In this thesis, super resolution ultrasound imaging technique was investigated by localizing individual microbubbles (MBs) in a capillary tube. The programmable Verasonics Research System with a 128-element linear transducer array was used to conduct experiments. Different sequences were developed and their performance were evaluated in imaging experiments of coherent compounding plane wave imaging (CPCW) and pulse inversion (PI) with compounding angles. For removing tissue signals and detecting MBs; differential imaging (DI), PI and singular value decomposition (SVD) filtering techniques were implemented successfully. Ultrasound imaging system was characterized in terms of lateral and axial resolution by extracting point spread function (PSF) for different imaging modalities. Furthermore, acoustic radiation force (ARF) was combined with ultrafast ultrasound imaging in order to direct MBs towards the bottom wall of the capillary tube. Effect of using different transmit voltages, flow rates and number of angles was evaluated in terms of via image quality metrics such as contrast to tissue ratio (CTR), contrast to noise ratio (CNR).

Subject Keywords

High Frame Rate Imaging, Super Resolution Ultrasound, Microbubble, Ultrasound Imaging, Transducer

URI

https://hdl.handle.net/11511/96075

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

E. B. Berberoğlu, “Development and Implementation of Ultrafast Ultrasound Imaging,” M.S. - Master of Science, Middle East Technical University, 2022.