Construction of a New Model to Investigate Breast Cancer Data

2021-01-01
Ağyüz, Umut
Purutçuoğlu Gazi, Vilda
Purutçuoğlu, Eda
ÜRÜN, YÜKSEL
© 2021, Springer Nature Switzerland AG.Modelling is a way to describe the elements of the network/system, their states and their interactions with other elements in order to understand the current state of knowledge of a system. Thereby, the mathematical models may predict the experiments which are difficult or impossible to do in the lab and can be used to discover indirect relationships between model’s components. Hereby, the aim of this study is to develop a network structure for the breast cancer from the analyses of different datasets which include the data of the luminal type at the stage 1–3 breast cancer diagnosed in total 377 patients and related to the PI3KCD signalling pathway. Accordingly, in the analyses, the relations of the 65 oncogenes are revealed by a true network in a binary format. Then, we construct the quasi breast cancer networks by using different parametric and non-parametric models, namely, Gaussian graphical model, copula Gaussian graphical model and multivariate adaptive regression splines with/without interaction terms. In the computations, we evaluate the performance of all suggested mathematical models via F-measure and accuracy measure criteria. We consider that the outcomes can be useful for the selection of the best fitted model in the construction of the breast cancer gene-gene interaction networks.
6th International Conference on Dynamics Games and Science, DGS-VI-2018, 19th Latin American Conference on Economic Theory, JOLATE 2018 and 21st International Consortium on Applied Bioeconomy Research, ICABR 2017

Suggestions

An integrative explanation of action
Benı, Majıd Davoody (Elsevier BV, 2020-12-01)
The Predictive Processing Theory (PP) and its foundational Free Energy Principle (FEP) provide a unifying theoretical groundwork that subsumes theories of perception, cognition, and action. Recently Colin Klein (2018) contends that PP-FEP cannot explain adaptive action with the same force that they deal with perceptions. In his answer to the objection, Clark (2020) points out that FEP explains action, desire and motivation on the basis of minimisation of energy. I argue that this answer begs the question of...
Examination of Computer Supported Collaborative Business Process Modeling with Activity Theory
FINDIK COŞKUNÇAY, DUYGU; Çakır, Murat Perit (2014-09-10)
Activity Theory provides a framework to examine and explain human-human and human-computer interactions. In this study, Activity Theory was used to examine both interactions in depth in the context of Computer Supported Collaborative Business Process Modeling (CSCBPM) in which geographically dispersed multiple users interact with each other and with the system. This framework enabled us to examine the activities of CSCBPM in detail and understand the process of CSCBPM. During the CSCBPM, some difficulties w...
Novel model selection criteria on high dimensionalbiological networks
Bülbül, Gül Baha; Purutçuoğlu Gazi, Vilda; Department of Statistics (2019)
Gaussian graphical model (GGM) is an useful tool to describe the undirected associ-ations among the genes in the sparse biological network. To infer such high dimen-sional biological networks, thel1-penalized maximum-likelihood estimation methodis used. This approach performs a variable selection procedure by using a regular-ization parameter which controls the sparsity in the network. Thus, a selection ofthe regularization parameter becomes crucial to define the true interactions in the bi-ological ne...
On the Orthogonality of q-Classical Polynomials of the Hahn Class
Alvarez-Nodarse, Renato; Adiguzel, Rezan Sevinik; Taşeli, Hasan (2012-01-01)
The central idea behind this review article is to discuss in a unified sense the orthogonality of all possible polynomial solutions of the q-hypergeometric difference equation on a q-linear lattice by means of a qualitative analysis of the q-Pearson equation. To be more specific, a geometrical approach has been used by taking into account every possible rational form of the polynomial coefficients in the q-Pearson equation, together with various relative positions of their zeros, to describe a desired q-wei...
Investigation of electromagnetic wave propagation in double negative materials
Şen, Saffet Gökçen; Kuzuoğlu, Mustafa; Department of Electrical and Electronics Engineering (2008)
This thesis analyzes some aspects of electromagnetic wave propagation in double negative materials. Double negative materials have negative refractive indices. They are backward-wave materials. Plane waves undergo negative refraction at interfaces between double positive and double negative media. Causality principle implies these properties. High frequency plane wave scattering from a double negative infinitely long cylinder has been analyzed by using modified Watson transform, geometrical optics and Mie s...
Citation Formats
U. Ağyüz, V. Purutçuoğlu Gazi, E. Purutçuoğlu, and Y. ÜRÜN, “Construction of a New Model to Investigate Breast Cancer Data,” California, Amerika Birleşik Devletleri, 2021, vol. 365, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85116944324&origin=inward.