Functionalization of graphene oxide quantum dots for anticancer drug delivery

Date

2023-02-01

Author

Mohammed-Ahmed, Heba K.
Nakipoğlu, Mustafa
Tezcaner, Ayşen
Keskin, Dilek
Evis, Zafer

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

180
views

0
downloads

Graphene quantum dots (GQDs) have a wide range of applications in biomedical applications, particularly anticancer drug delivery. In this study, graphene oxide quantum dots conjugated with glucosamine and boric acid (GOQDs-GlcN-BA) with and without doxorubicin (DOX) were investigated for cancer therapy for the first time in the literature. The nanocomposite contained 4 w/w boron according to the ICP analysis. Furthermore, the size of the nanocomposites ranged between 15 and 51 nm. DOX loading efficiencies of GOQDs-GlcN-DOX and GOQDs-GlcN-BA-DOX were 57% and 90%, respectively. Only 8% of DOX release occurred from GOQDs-GlcN-DOX in acidic environment and 5% of drug released at neutral pH, whereas BA addition in the nanocomposite increased DOX release up to 20% at 5.5 pH and 10% at 7.4 pH in 96 h. GOQD-GlcN-BA-DOX exhibited more cytotoxicity against MCF-7 cells compared to GOQD-GlcN-DOX. Cellular internalization of GOQD-GlcN-BA-DOX in MCF-7 was higher than it was observed for GOQDs-GlcN-DOX owing to sialic acid-BA interaction on cell surface. This work shows the incorporation of BA to the nanocomposite enhanced the loading and release of DOX, with higher cellular internalization, thus superior potential for anticancer drug delivery.

Subject Keywords

Anticancer drug delivery, Boric acid, Doxorubicin, Graphene oxide, Nanocomposite, Quantum dot

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146838048&origin=inward
https://hdl.handle.net/11511/102193

Journal

Journal of Drug Delivery Science and Technology

DOI

https://doi.org/10.1016/j.jddst.2023.104199

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Synthesis and functionalization of graphene oxide nanocomposites for anticancer drug delivery Kamal Mohammed Ahmed Hassan, Heba; Evis, Zafer; Tezcaner, Ayşen; Department of Biomedical Engineering (2022-6-27) Graphene, graphene quantum dots (GQDs) their derivatives and gold nanoparticles (AuNPs), all have a wide range of applications in biomedical applications, particularly anticancer drug delivery, due to their large surface area, chemical and mechanical stability, and good biocompatibility. The first goal of this research is to improve the chemistry and solubility of rGO by doping it with boron and decorating it with AuNPs (Au-B-rGO), as well as to improve the loading efficiency of the anticancer drug doxorubi...
Biopolymer based micro/nanoparticles as drug carriers for the treatment of skin diseases Eke, Gözde; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Department of Micro and Nanotechnology (2011) Controlled drug delivery systems are becoming increasingly interesting with the contribution of nanotechnology. In the case of transdermal applications the greatest limitation is the highly impermeable outermost layer of the skin, the stratum corneum. One promising method of controlled transdermal drug delivery of the skin therapeutics is the use of nanoparticles as carriers. Encapsulation of the drug, as opposed to classical topical application of creams or emulsions, allows the drug to diffuse into hair f...
Core/shell type, Ce3+ and Tb3+ doped GdBO3 system: Synthesis and Celecoxib drug delivery application Çolak, Pelin; Ulusan, Sinem; Banerjee, Sreeparna; Yılmaz, Ayşen (Elsevier BV, 2020-12-01) In this study, luminescent and magnetic core/shell Gd1-x-yCexTbyBO3@SiO2 nanoparticles were synthesized and used to design a drug delivery system for Celecoxib (CLX). CLX was chosen as the model drug because it is a nonsteroidal anti-inflammatory drug that is highly hydrophobic with relatively low bioavailability. The core was synthesized by Pechini sol-gel method and silica coating was carried out by a Modified Stöber method. Drug loading was carried out in ethanol with high efficiency and an improved drug...
Investigation of in vitro cytotoxic effects of heparin coated iron oxide nanoparticles combined with tpp-dca on human hepatocellular carcinoma cell line HEPG2 Saraç, Başak Ezgi; Güray, Nülüfer Tülün; Volkan, Mürvet; Department of Biology (2018) Nanotechnology in medicine involves the applications of nanoparticles and one of the rising field is cancer nanotechnology, which has been increasingly used in cancer diagnostics, imaging, and therapeutic drug delivery. The advantage of the use of the nanoparticles is that, they can be designed to be specific for tumor tissue. This allows increased drug delivery efficiency and reduced off-target toxicities. Iron oxide nanoparticles used in this study are smaller than 100 nm but still it gives an enhanced su...
Synthesis and Characterization of Multifunctional GdB3O6/Ca10(PO4)6(OH)2 Core/Shell Particles for Biomedical Applications Uzun, Mehmet Burak; Yılmaz, Ayşen; Department of Chemistry (2023-1-06) Multifunctional particles with multiple properties are used in biomedical applications for cancer treatment. With the recently developing technology, particles with photoluminescent properties can perform real-time imaging. In this study, Ce3+/Tb3+ co-doped, Eu3+ doped GdB3O6 particles were synthesized, coated with hydroxyapatite (HAP) and polyethylene glycol (PEG). Then, particles were loaded with doxorubicin. Ce3+/Tb3+ co-doped and Eu3+ doped GdB3O6 particles were synthesized by the sol-gel process using ...

Citation Formats

H. K. Mohammed-Ahmed, M. Nakipoğlu, A. Tezcaner, D. Keskin, and Z. Evis, “Functionalization of graphene oxide quantum dots for anticancer drug delivery,” Journal of Drug Delivery Science and Technology, vol. 80, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146838048&origin=inward.