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Early Postoperative Adjuvant Radiotherapy Versus Active Monitoring After Gross Total Resection for Atypical Meningiomas: Factors Associated with Early Recurrence
Date
2023-01-01
Author
GÜRSES, MUHAMMET ENES
ZENGİN, HATİCE YAĞMUR
Shikhaliyeva, Aysel
Aşkun, Cengiz Savaş
Mut, Melike
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AIM: To investigate the predictors of recurrence after gross total resection (GTR) that require early adjuvant radiotherapy upfront rather than at initial recurrence of atypical meningiomas (AMs). MATERIAL and METHODS: A retrospective study of gross totally resected AMs was conducted in a tertiary care center within ten years. The clinical, radiological, and pathological parameters were analyzed statistically, and the factors associated with recurrence after GTR were determined with univariate analysis. RESULTS: Among 23 AMs with GTR, 34.8% showed recurrence in a median follow-up of 40 months after the surgery. Preoperative tumor volume, tumor location in the skull base or tentorium, and lack of progesterone expression were associated with the higher recurrence rate. AMs with a preoperative volume of 27.5 cm3 were the most significant risk factor for the recurrence (a 9.3-fold increase) than those with 27.5 cm3) might have higher recurrence rates after GTR and, therefore, would benefit from early adjuvant radiotherapy without waiting for a recurrence. AMs located in the skull base or tentorium and AMs having no progesterone expression might also be potential predictors for recurrence.
Subject Keywords
Atypical
,
Meningioma
,
Radiotherapy
,
Recurrence
,
Resection
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166165172&origin=inward
https://hdl.handle.net/11511/104927
Journal
Turkish Neurosurgery
DOI
https://doi.org/10.5137/1019-5149.jtn.41369-22.1
Collections
Department of Computer Education and Instructional Technology, Article
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BibTeX
M. E. GÜRSES, H. Y. ZENGİN, A. Shikhaliyeva, C. S. Aşkun, and M. Mut, “Early Postoperative Adjuvant Radiotherapy Versus Active Monitoring After Gross Total Resection for Atypical Meningiomas: Factors Associated with Early Recurrence,”
Turkish Neurosurgery
, vol. 33, no. 4, pp. 635–641, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166165172&origin=inward.