Early Postoperative Adjuvant Radiotherapy Versus Active Monitoring After Gross Total Resection for Atypical Meningiomas: Factors Associated with Early Recurrence

Date

2023-01-01

Author

GÜRSES, MUHAMMET ENES
ZENGİN, HATİCE YAĞMUR
Shikhaliyeva, Aysel
Aşkun, Cengiz Savaş
Mut, Melike

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AIM: To investigate the predictors of recurrence after gross total resection (GTR) that require early adjuvant radiotherapy upfront rather than at initial recurrence of atypical meningiomas (AMs). MATERIAL and METHODS: A retrospective study of gross totally resected AMs was conducted in a tertiary care center within ten years. The clinical, radiological, and pathological parameters were analyzed statistically, and the factors associated with recurrence after GTR were determined with univariate analysis. RESULTS: Among 23 AMs with GTR, 34.8% showed recurrence in a median follow-up of 40 months after the surgery. Preoperative tumor volume, tumor location in the skull base or tentorium, and lack of progesterone expression were associated with the higher recurrence rate. AMs with a preoperative volume of 27.5 cm3 were the most significant risk factor for the recurrence (a 9.3-fold increase) than those with 27.5 cm3) might have higher recurrence rates after GTR and, therefore, would benefit from early adjuvant radiotherapy without waiting for a recurrence. AMs located in the skull base or tentorium and AMs having no progesterone expression might also be potential predictors for recurrence.

Subject Keywords

Atypical, Meningioma, Radiotherapy, Recurrence, Resection

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85166165172&origin=inward
https://hdl.handle.net/11511/104927

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Department of Computer Education and Instructional Technology, Article