Tissue engineered retinal pigment epithelium

Tezcaner, Ayşen


Interdependence of pulsed ultrasound and shear stress effects on cell morphology and gene expression
Mccormick, Susan M.; Saini, Vikas; Yazıcıoğlu, Yiğit; Demou, Zoe N.; Royston, Thomas J. (Springer Science and Business Media LLC, 2006-03-01)
Fluid shear stress is a key biomechanical regulatory factor in a several biological systems including bone tissue. Bone cells are also regulated by exogenous acoustic vibration, which has therapeutic benefits. In this study, we determined the effects of shear stress and pulsed ultrasound (US), alone and in series on osteoblast morphology and gene expression. We observed that shear stress (19 dyne/cm(2)) elongated SaOS-2 cells at 3, 6, 24, and 48 h decreasing their shape index from control values of 0.51 +/-...
Limestone decay in historic monuments and consolidation with nanodispersive calcium hydroxide solutions
Caner, Evin; Saltık, Emine Nevin; Restoration in Department of Architecture (2011)
Exposure to atmospheric conditions results of deterioration in historic monuments. and their stones. Limestone conservation presents many problems that have to be investigated in detail. In this study, limestone deterioration and development of its conservation treatments were investigated through examination of the statues carved from karstic limestones in Nemrut Dağ Monument. The decay mechanisms that had major roles in their deterioration during two thousand years of exposure to atmospheric conditions an...
Dual growth factor delivery using PLGA nanoparticles in silk fibroin/PEGDMA hydrogels for articular cartilage tissue engineering
Fathi-Achachelouei, Milad; Keskin, Dilek; Bat, Erhan; Vrana, Nihal E.; Tezcaner, Ayşen (Wiley, 2020-07-01)
Degeneration of articular cartilage due to damages, diseases, or age-related factors can significantly decrease the mobility of the patients. Various tissue engineering approaches which take advantage of stem cells and growth factors in a three-dimensional constructs have been used for reconstructing articular tissue. Proliferative impact of basic fibroblast growth factor (bFGF) and chondrogenic differentiation effect of transforming growth factor-beta 1 (TGF-beta 1) over mesenchymal stem cells have previou...
Bone tissue generation on biodegradable polymeric scaffolds
Torun Köse, Gamze; Hasırcı, Vasıf Nejat; Korkusuz, Feza; Department of Biotechnology (2002)
In the present study, tissue engineered bone was produced on calcium phosphate loaded collagen and PHBV8 matrices. Osteoblasts isolated from rat bone marrow were characterized by light microscopy, alkaline phosphatase (ALP) activity, osteocalcin determination assay, and Western blots for integrin. Population doubling time of the cells was found as 50 ± 2 h at 37 °C in a CO2 incubator. PHBV8 foams iiiwere treated with rf-oxygen plasma to modify their surface chemistry and hydrophilicity to increase the reatt...
Analyzing the incidence and causes offield of study mismatch in Turkey: evidence from TURKSTAT labor force surveys
Ege, Ahmet Alper; Erdil, Erkan; Department of Science and Technology Policy Studies (2020)
Field of study mismatch occurs when attained field of study is different from field of study required for doing the job well. Using TURKSTAT labor force surveys, this thesis attempts to analyze incidence level and causes of field of study mismatch in Turkey. Mismatch is measured by using coding scheme. Its determinants are analyzed by estimating binary logistic regression model, with an emphasis on the effect of labor market conditions. Analysis of incidences indicates that Turkey has high incidence of mism...
Citation Formats
A. Tezcaner, “Tissue engineered retinal pigment epithelium,” Ph.D. - Doctoral Program, Middle East Technical University, 2001.