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Sialic Acid-Functionalized Gold Nanoparticles for Sensitive and Selective Colorimetric Determination of Serotonin
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avcı-et-al-2024-sialic-acid-functionalized-gold-nanoparticles-for-sensitive-and-selective-colorimetric-determination-of.pdf
Date
2024-06-04
Author
Avcı, Begüm
Akpınar, Yeliz
Ertaş, Gülay
Volkan, Mürvet
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We present a novel colorimetric method inspired by nature’s complex mechanisms, capable of selectively determining serotonin with high sensitivity. This method exploits the inherent binding affinity of serotonin with sialic acid (SA) molecules anchored to gold nanoparticles (SA-AuNPs). Upon serotonin binding, SA-AuNPs aggregate, and a characteristic red shift in the absorbance of SA-AuNPs accompanied by a dramatic color change (red to blue) occurs, readily observable even without instrumentation. The proposed method effectively eliminates interventions from potential interfering species such as dopamine, epinephrine, l-tyrosine, glucosamine, galactose, mannose, and oxalic acid. The absence of a color change with l-tryptophan, a structurally related precursor of serotonin, further confirms the high selectivity of this approach for serotonin detection. The colorimetric method has a wide linear dynamic range (0.05-1.0 μM), low limit of detection (0.02 μM), and fast response time (5 min). The limit of detection of the method is lower than other colorimetric serotonin sensors reported so far. The possible use of the proposed method in biological sample analysis was evaluated by employing a serotonin recovery assay in processed human plasma. The recoveries ranged from 90.5 to 104.2%, showing promising potential for clinical applications.
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85194283065&origin=inward
https://hdl.handle.net/11511/109916
Journal
ACS Omega
DOI
https://doi.org/10.1021/acsomega.4c01859
Collections
Department of Chemistry, Article
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BibTeX
B. Avcı, Y. Akpınar, G. Ertaş, and M. Volkan, “Sialic Acid-Functionalized Gold Nanoparticles for Sensitive and Selective Colorimetric Determination of Serotonin,”
ACS Omega
, vol. 9, no. 22, pp. 23832–23842, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85194283065&origin=inward.