Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity
Download
1-s2.0-S2211124724006545-main.pdf
Date
2024-06-25
Author
Batorsky, Rebecca
Ceasrine, Alexis M.
Shook, Lydia L.
Kışlal, Sezen
Bordt, Evan A.
Devlin, Benjamin A.
Perlis, Roy H.
Slonim, Donna K.
Bilbo, Staci D.
Edlow, Andrea G.
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
70
views
23
downloads
Cite This
Maternal immune activation is associated with adverse offspring neurodevelopmental outcomes, many mediated by in utero microglial programming. As microglia remain inaccessible throughout development, identification of noninvasive biomarkers reflecting fetal brain microglial programming could permit screening and intervention. We used lineage tracing to demonstrate the shared ontogeny between fetal brain macrophages (microglia) and fetal placental macrophages (Hofbauer cells) in a mouse model of maternal diet-induced obesity, and single-cell RNA-seq to demonstrate shared transcriptional programs. Comparison with human datasets demonstrated conservation of placental resident macrophage signatures between mice and humans. Single-cell RNA-seq identified common alterations in fetal microglial and Hofbauer cell gene expression induced by maternal obesity, as well as sex differences in these alterations. We propose that Hofbauer cells, which are easily accessible at birth, provide insights into fetal brain microglial programs and may facilitate the early identification of offspring vulnerable to neurodevelopmental disorders.
Subject Keywords
CP: Immunology
,
CP: Metabolism
,
fetal programming
,
Hofbauer cells
,
microglia
,
mouse
,
neuroimmune
,
obesity
,
sex differences
,
single-cell RNA sequencing
URI
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85195090397&origin=inward
https://hdl.handle.net/11511/109939
Journal
Cell Reports
DOI
https://doi.org/10.1016/j.celrep.2024.114326
Collections
Department of Psychology, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
R. Batorsky et al., “Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity,”
Cell Reports
, vol. 43, no. 6, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85195090397&origin=inward.