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Exploiting Matrix Stiffness to Overcome Drug Resistance
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aydin-et-al-2024-exploiting-matrix-stiffness-to-overcome-drug-resistance.pdf
Date
2024-07-05
Author
Aydin, Hakan Berk
Özçelikkale, Altuğ
Acar, Ahmet
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Drug resistance is arguably one of the biggest challenges facing cancer research today. Understanding the underlying mechanisms of drug resistance in tumor progression and metastasis are essential in developing better treatment modalities. Given the matrix stiffness affecting the mechanotransduction capabilities of cancer cells, characterization of the related signal transduction pathways can provide a better understanding for developing novel therapeutic strategies. In this review, we aimed to summarize the recent advancements in tumor matrix biology in parallel to therapeutic approaches targeting matrix stiffness and its consequences in cellular processes in tumor progression and metastasis. The cellular processes governed by signal transduction pathways and their aberrant activation may result in activating the epithelial-to-mesenchymal transition, cancer stemness, and autophagy, which can be attributed to drug resistance. Developing therapeutic strategies to target these cellular processes in cancer biology will offer novel therapeutic approaches to tailor better personalized treatment modalities for clinical studies.
URI
https://hdl.handle.net/11511/110225
Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
DOI
https://doi.org/10.1021/acsbiomaterials.4c00445
Collections
Department of Mechanical Engineering, Article
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BibTeX
H. B. Aydin, A. Özçelikkale, and A. Acar, “Exploiting Matrix Stiffness to Overcome Drug Resistance,”
ACS BIOMATERIALS SCIENCE & ENGINEERING
, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://hdl.handle.net/11511/110225.