READv2: advanced and user-friendly detection of biological relatedness in archaeogenomics

Date

2024-12-01

Author

Alaçamlı, Erkin
Naidoo, Thijessen
Güler, Murat
Sağlıcan, Ekin
Aktürk, Şevval
Mapelli, Igor
Vural, Kıvılcım Başak
Somel, Mehmet
Malmström, Helena
Günther, Torsten

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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The advent of genome-wide ancient DNA analysis has revolutionized our understanding of prehistoric societies. However, studying biological relatedness in these groups requires tailored approaches due to the challenges of analyzing ancient DNA. READv2, an optimized Python3 implementation of the most widely used tool for this purpose, addresses these challenges while surpassing its predecessor in speed and accuracy. For sufficient amounts of data, it can classify up to third-degree relatedness and differentiate between the two types of first-degree relatedness, full siblings and parent-offspring. READv2 enables user-friendly, efficient, and nuanced analysis of biological relatedness, facilitating a deeper understanding of past social structures.

Subject Keywords

Ancient DNA, Archaeogenomics, Kinship, Relatedness, Software

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85201252750&origin=inward
https://hdl.handle.net/11511/111144

Collections

Department of Civil Engineering, Article