Production and biological properties of nano porous glass microparticles for anticancer drug carrier

2024-09-01
Ertuş, Emre Burak
Gulbahce-Mutlu, Elif
Alpa, Serife
Öztürk, Abdullah
Nanoporous glass (NPG) microparticles were produced by conventional melt-quenching followed by acid-alkali leaching to get material for anticancer drug carriers. NPG exhibited a positive zeta potential of 34 mV after [3-(2-aminoethylamino) propyl] trimethoxysilane treatment. The specific surface area and the total pore volume of NPG were 47.3 m2/g and 0.692 cm3/g, respectively. The 5-Fluorouracil (5FU) loading capacity of NPG was measured as 18.2 ± 0.2 mg5FU/gNPG. The drug release rate was monitored for 120 hours. To evaluate the cytotoxic effects of NPG on both MCF-7 breast cancer cells and MCF-12A, an immortalized cell line, the study employed the 2, 3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium5-carboxanilide inner salt (XTT) assay. The XTT results revealed that NPG showed a time and concentration-dependent cytotoxic effect. It is anticipated that NPG is a safe and effective material for drug delivery systems for in vitro and a promising alternative material for in vivo applications.
Journal of Applied Pharmaceutical Science
Citation Formats
E. B. Ertuş, E. Gulbahce-Mutlu, S. Alpa, and A. Öztürk, “Production and biological properties of nano porous glass microparticles for anticancer drug carrier,” Journal of Applied Pharmaceutical Science, vol. 14, no. 9, pp. 120–127, 2024, Accessed: 00, 2024. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85203345007&origin=inward.