Production and biological properties of nano porous glass microparticles for anticancer drug carrier

Date

2024-09-01

Author

Ertuş, Emre Burak
Gulbahce-Mutlu, Elif
Alpa, Serife
Öztürk, Abdullah

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Nanoporous glass (NPG) microparticles were produced by conventional melt-quenching followed by acid-alkali leaching to get material for anticancer drug carriers. NPG exhibited a positive zeta potential of 34 mV after [3-(2-aminoethylamino) propyl] trimethoxysilane treatment. The specific surface area and the total pore volume of NPG were 47.3 m2/g and 0.692 cm3/g, respectively. The 5-Fluorouracil (5FU) loading capacity of NPG was measured as 18.2 ± 0.2 mg5FU/gNPG. The drug release rate was monitored for 120 hours. To evaluate the cytotoxic effects of NPG on both MCF-7 breast cancer cells and MCF-12A, an immortalized cell line, the study employed the 2, 3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium5-carboxanilide inner salt (XTT) assay. The XTT results revealed that NPG showed a time and concentration-dependent cytotoxic effect. It is anticipated that NPG is a safe and effective material for drug delivery systems for in vitro and a promising alternative material for in vivo applications.

Subject Keywords

5FU, breast cancer, drug release, MCF7, Porous glass

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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85203345007&origin=inward
https://hdl.handle.net/11511/111188

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Department of Metallurgical and Materials Engineering, Article