Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Synthesis and photoluminescence properties of Ce3+/Tb3+ and Eu3+ ions doped GdB3O6/Ca10(PO4)6(OH)2 Core/Shell particles as well as its cytotoxicity against colon cancer cells
Download
index.pdf
Date
2024-09-01
Author
Yılmaz, Ayşen
Banerjee, Sreeparna
Güderer, İsmail
Uzun, Mehmet Burak
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
28
views
0
downloads
Cite This
In this study, Ce3+/Tb3+ co-doped, Eu3+ doped GdB3O6 phosphor particles were synthesized by sol-gel method,coated with hydroxyapatite (HAP) and loaded with doxorubicin. Different chelating agents and surfactants(Cetyltrimethylammonium bromide (CTAB), citric acid, glycine, ethylenediaminetetraacetic acid (EDTA) andtartaric acid) were used in the synthesis in order to see their effect on the structure. While single phase Gadoliniumtriborate, GdB3O6 was obtained by using CTAB in precursor solution in the synthesis and Gadoliniumorthoborate, GdBO3 produced when EDTA was used in precursor solution. Other organic molecules added toprecursor solution produced mixtures of both phases. The highest photoluminescence intensity was obtained inthe Gd0.95Ce0.025Tb0.025B3O6 and Gd0.825Eu0.175B3O6. In order to increase the drug loading efficiency, TheGd0.825Eu0.175B3O6 core was coated with Calcium hydroxyapatite, HAP. The core had an average size of 458.65nm which increased to 616.85 nm after coating as seen with dynamic light scattering (DLS). Gd0.825Eu0.175B3O6@HAP particles were loaded with 7.82 % ± 0.80 wt doxorubicin and the release was studied at 37 ◦C in pH7.4 phosphate-buffered saline (PBS) and pH 5.5 acetate buffer solutions. The total number of moles of drugreleased versus luminescence intensity was measured during the release studies and real-time imaging studieswere carried out. Finally, cytotoxicity experiments were performed on HCT-116 colon cancer cells.
URI
https://hdl.handle.net/11511/111256
Journal
JOURNAL OF MOLECULAR STRUCTURE
DOI
https://doi.org/10.1016/j.molstruc.2024.139921
Collections
Department of Chemistry, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
A. Yılmaz, S. Banerjee, İ. Güderer, and M. B. Uzun, “Synthesis and photoluminescence properties of Ce3+/Tb3+ and Eu3+ ions doped GdB3O6/Ca10(PO4)6(OH)2 Core/Shell particles as well as its cytotoxicity against colon cancer cells,”
JOURNAL OF MOLECULAR STRUCTURE
, vol. 1321, pp. 139921–139932, 2024, Accessed: 00, 2024. [Online]. Available: https://hdl.handle.net/11511/111256.