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Design, synthesis, and evaluation of novel Indole-Based small molecules as sirtuin inhibitors with anticancer activities.
Date
2024-11-01
Author
Binarci, Busra
Kilic, Ensar Korkut
Dogan, Tunca
Cetin Atalay, Rengul
Kahraman, Deniz Cansen
Nacak Baytas, Sultan
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Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, driven mainly by chronic hepatitis infections and metabolic disorders, which highlights the urgent need for novel therapeutic strategies. Sirtuins, particularly SIRT1 are crucial in HCC pathogenesis, making it a promising drug target. Indole-based molecules show potential as therapeutic agents by interacting with key proteins like sirtuins involved in cancer progression. In this study, we designed and synthesized novel indole-based small molecules and investigated their potential sirtuin inhibitory action and anticancer activity on HCC cell lines. Four of the twenty-eight tested small molecules on different cancer types were selected (4 g, 4 h, 4o, and 7j) based on their structure–activity relationship and studied on a panel of HCC cell lines. Compounds had active drug-target interactions with SIRT1 or SIRT2 based on DEEPScreen DTI predictions and docking studies which confirmed that 4o, 4 g, and 7j were most potent in their interaction with SIRT1. Compound 4 g caused the highest sirtuin activity inhibition in vitro and induced G1 arrest and apoptosis in HCC cell lines.
URI
https://hdl.handle.net/11511/111867
Journal
Drug development research
DOI
https://doi.org/10.1002/ddr.70008
Collections
Graduate School of Informatics, Article
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BibTeX
B. Binarci, E. K. Kilic, T. Dogan, R. Cetin Atalay, D. C. Kahraman, and S. Nacak Baytas, “Design, synthesis, and evaluation of novel Indole-Based small molecules as sirtuin inhibitors with anticancer activities.,”
Drug development research
, vol. 85, no. 7, 2024, Accessed: 00, 2024. [Online]. Available: https://hdl.handle.net/11511/111867.