INVESTIGATION OF THE ROLE OF THE SEROTONIN 2C RECEPTOR POLYMORPHISMS IN ANTIDEPRESSANT-ASSOCIATED WEIGHT CHANGE IN TURKISH POPULATION

Date

2024-11-26

Author

Üzel, Uğur

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Major depressive disorder (MDD) and anxiety disorders have become highly prevalent in recent years, especially following the COVID-19 pandemic. Although selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for these disorders, weight change is a significant side effect that may interfere with patient adherence to treatment and could also lead to additional health problems. A serotonin receptor subtype, serotonin 2C receptor (5-HT2CR), regulates feeding behavior through hypothalamic pathways. This project aimed to investigate the role of three 5-HT2CR polymorphisms: -759C/T, -697G/C, and 68G/C (Cys23Ser), previously linked to weight or feeding abnormalities, in SSRI-associated weight change in a small patient group in Türkiye. Due to its clinical convenience, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine polymorphic alleles. Weight changes were analyzed in relation to the alleles and the administered SSRIs after 4 weeks of SSRI use. The findings indicated that baseline body mass index (BMI) was higher in carriers of the -697C allele, who were more common in our study population.

Subject Keywords

SSRI, Antidepressant, Serotonin 2C Receptor, Weight Change, SNP

URI

https://hdl.handle.net/11511/112635

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Graduate School of Natural and Applied Sciences, Thesis