Recent Developments in Glioblastoma-On-A-Chip for Advanced Drug Screening Applications

Date

2024-01-01

Author

Maity, Surjendu
Bhuyan, Tamanna
Jewell, Christopher
Kawakita, Satoru
Sharma, Saurabh
Nguyen, Huu Tuan
Hassani Najafabadi, Alireza
Ermiş Şen, Menekşe
Falcone, Natashya
Chen, Junjie
Mandal, Kalpana
Khorsandi, Danial
Yilgor, Can
Choroomi, Auveen
Torres, Emily
Mecwan, Marvin
John, Johnson V.
Akbari, Mohsen
Wang, Zhaohui
Moniz-Garcia, Diogo
Quiñones-Hinojosa, Alfredo
Jucaud, Vadim
Dokmeci, Mehmet Remzi
Khademhosseini, Ali

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

0
views

0
downloads

Cite This

Glioblastoma (GBM) is an aggressive form of cancer, comprising ≈80% of malignant brain tumors. However, there are no effective treatments for GBM due to its heterogeneity and the presence of the blood-brain barrier (BBB), which restricts the delivery of therapeutics to the brain. Despite in vitro models contributing to the understanding of GBM, conventional 2D models oversimplify the complex tumor microenvironment. Organ-on-a-chip (OoC) models have emerged as promising platforms that recapitulate human tissue physiology, enabling disease modeling, drug screening, and personalized medicine. There is a sudden increase in GBM-on-a-chip models that can significantly advance the knowledge of GBM etiology and revolutionize drug development by reducing animal testing and enhancing translation to the clinic. In this review, an overview of GBM-on-a-chip models and their applications is reported for drug screening and discussed current challenges and potential future directions for GBM-on-a-chip models.

Subject Keywords

disease modeling, drug screening, GBM, GBM-on-a-chip, tumor microenvironment

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85208934284&origin=inward
https://hdl.handle.net/11511/112765

Collections

Biomaterials and Tissue Engineering Application and Research Center (BİOMATEN), Article