Overcoming the Barriers of Brain Cancer Treatment: Targeted and Fully NIR Absorbing Photodynamic Therapy Agents with Extremely Low Molecular Weights and Controlled Lipophilicity

Date

2025-10-31

Author

Günbaş, Emrullah Görkem

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Photodynamic therapy for brain tumours ; Brain cancer has a dismal five-year survival rate due to the high percentage of inoperable tumours and the limited number of drugs that can pass through the blood–brain barrier. Therefore, there is an imminent need for effective targeted brain cancer therapies. Scientists of the EU-funded INFRADYNAMICS project are working on photodynamic therapy (PDT), a type of therapy that combines light and a photosensitising drug to kill cancer cells. The key objective is to develop PDT agents capable of specific deep tissue penetration, infrared light absorption and high oxygen generation efficiency. Alongside the characterisation of their photophysical properties, the generated PDT agents will be tested on glioblastoma cells for effectiveness.

Subject Keywords

photodynamic therapy, NIR absorption, m-IDH1, targeted cancer therapy

URI

https://cordis.europa.eu/project/id/852614
https://users.metu.edu.tr/ggunbas/infradynamics.html
https://hdl.handle.net/11511/113419

Collections

Department of Chemistry, Project and Design