New electrospinning strategies for the preparation of solid-phase microextraction coatings

Date

2025-1-8

Author

Şahin, Alper

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

32
views

15
downloads

Cite This

Solid phase microextraction (SPME) is a well-known, versatile sample preparation technique with several critical advantages. The versatility of SPME comes from the availability of a large variety of extractive phases and homemade coating preparation methods. However, in SPME, the extractive particles are immobilized in the bulk phase on the surface of support, which decreases the diffusion of analytes within the phase and the kinetic of extraction. This can be eliminated using nanofibrous extractive phases developed directly on the support without needing a bulk polymeric immobilizer, resulting in faster extraction kinetics and fast analysis. Production of nanofibrous extractive phase-coated SPME samplers is possible using an electrospinning process with the advantage of direct deposition of nano- and micro-fibrous polymers on the surface of a support. In this study, two new electrospinning strategies for the SPME probe preparation were proposed. The first strategy included a novel extractive phase preparation method based on imprinting the analyte during the electrospinning. Templates (trifluralin and carbaryl) were immobilized into a ready-made polymer (polyacrylonitrile) using electrospinning to produce analyte-specific regions, enabling easier production and enhanced analyte-selective extraction. The second strategy was proposed to overcome the reproducibility issues of electrospinning. Opposing the traditional syringe electrospinning, a high voltage was applied to a sword-shaped blade with one drop of polymer mixture, containing poly(divinylbenzene) and polyacrylonitrile. This method provided more controllable production of SPME samplers with fast extraction kinetics. Both samplers were evaluated successfully in proof-of-concept studies using pesticides (trifluralin, carbaryl, diazinon, malathion, and parathion) frequently used in agricultural production.

Subject Keywords

Solid phase microextraction, Thin film microextraction, Molecularly imprinted polymer, Electrospinning, Coating method

URI

https://hdl.handle.net/11511/113429

Collections

Graduate School of Natural and Applied Sciences, Thesis