Mechanical and biological evaluation of β-dicalcium silicate/dicalcium phosphate-based cements: promising materials for biomedical applications

Date

2025-01-01

Author

Alshemary, Ammar Z.
Marandi, Almataz Bellah
Ali, Daver
Köse, Tuğba
Dalgic, Ali Deniz
Motameni, Ali
Evis, Zafer

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This study explores the synthesis and evaluation of β-Dicalcium silicate and Dicalcium phosphate-based cements for biomedical use. β-Tricalcium phosphate was synthesized using microwave-assisted wet precipitation, while β-Dicalcium silicate was prepared via the sol-gel method. Composites with varying β-Dicalcium silicate contents (20%, 30%, 40%) were formulated and characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, and Field emission scanning electron microscope analyses. The 40% β-Dicalcium silicate composite showed the highest compressive strength at 10.22 MPa. Antibacterial tests against Staphylococcus aureus revealed that gentamicin-loaded Dicalcium phosphate cement had superior properties. Cytotoxicity studies using the Osteogenic sarcoma cell line revealed that the β-Dicalcium Silicate /Dicalcium Phosphate composites supported better cell viability compared to pure Dicalcium phosphate cement, with the 20% β-Dicalcium silicate /Dicalcium phosphate composition being the most effective in promoting cell growth. These findings suggest that β-Dicalcium silicate /Dicalcium phosphate composites hold promise for biomedical applications.

Subject Keywords

antibacterial activity, Biocements, compressive strength, cytotoxicity, dicalcium phosphate, β-dicalcium silicate

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85217374252&origin=inward
https://hdl.handle.net/11511/113624

Collections

Department of Engineering Sciences, Article