Drug resistance mediated by MRP gene in breast cancer.

Abaan, Ogan Demir


Drug Resistance Effect on Metastasis by Activating EMT Pathway in Meningioma
Karakaya, İdil Gül; Özen, Can; Coşkun, Süleyman; Department of Biochemistry (2023-1-16)
Cancer is one of the leading and often fatal diseases in humans. Cancerous cells can arise within any tissue or organ in the body. Treatment of cancer includes but is not limited to radiotherapy, chemotherapy, immunotherapy, or targeted therapy options. Meningioma, one of the brain malignancies, is the subject of this research. As it is known, cancer cells can spread to other organs and this is called metastasis. Different biological pathways contribute to the migration of cells. Epithelial to mesenchymal t...
Drug resistant breast cancer cells overexpress ETS1 gene
Kars, Meltem Demirel; Iseri, Ozlem Darcansoy; Gündüz, Ufuk (2010-09-01)
Purpose. - Multidrug resistance (MDR) is resistance to wide range of structurally unrelated anticancer agents. MDR is a serious limitation to the effective chemotherapy. Involvement of ETS1 overexpression in upregulation of MDR1 gene expression is implicated. In the present study the aim was to assess the involvement of ETS1 and the genes, which encode the proteins interacting with ETS1 in drug resistant MCF-7 breast cancer cells.
Hasırcı, Vasıf Nejat (1993-09-15)
Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.
Takeshita, F; Gursel, I; Ishii, KJ; Suzuki, K; Gürsel, Mayda; Klinman, DM (2004-02-01)
Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG ...
Drug metabolism and apoptosis in HEPG2 cell line
Rustam, Samir; Güray, Tülin; İrtem Kartal, Deniz; Department of Biology (2017)
The liver is the principal site of drug metabolism. Drugs and other chemicals are all metabolized in the liver through the drug-metabolizing enzyme system. Metabolized drugs can have an effect on one another through crosstalk between drug metabolism pathways. Herbs used in folk and mainstream medicine, when taken together with drugs, can affect the rate at which drugs are processed by the liver. Salvia species are one of many herbal remedies which can be used together with prescribed drugs as part of altern...
Citation Formats
O. D. Abaan, “Drug resistance mediated by MRP gene in breast cancer.,” Middle East Technical University, 2002.