Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.

Date

2004-02-01

Author

Takeshita, F
Gursel, I
Ishii, KJ
Suzuki, K
Gürsel, Mayda
Klinman, DM

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

214
views

0
downloads

Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.

Subject Keywords

CpG DNA, TLR 9, PAMP, Signal transduction

URI

https://hdl.handle.net/11511/40127

Journal

Seminars in immunology

DOI

https://doi.org/10.1016/j.smim.2003.10.009

Collections

Department of Biology, Article

Suggestions

OpenMETU
Core

CpG DNA: recognition by and activation of monocytes. Klinman, DM; Takeshita, F; Gursel, I; Leifer, C; Ishii, KJ; Verthelyi, D; Gürsel, Mayda (2002-07-01) Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune response characterized by the activation of Ig- and cytokine-secreting cells. Synthetic oligonucleotides (ODNs) containing CpG motifs mimic this activity, triggering monocytes to proliferate, secrete and/or differentiate. Analysis of hundreds of novel ODNs led to the identification of two structurally distinct classes of CpG motif that differentially activate human monocytes. ODNs of the "K"-type interact with Toll-like recept...
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides. Ishii, KJ; Gursel, I; Gürsel, Mayda; Klinman, DM (2004-04-01) Bacterial DNA contains immunostimulatory CpG motifs that interact with toll-like receptor 9 on immune cells to stimulate the production of cytokines, chemokines and immunoglobulins. Synthetic oligodeoxynucleotides (ODNs) containing CpG motifs mimic the activity of bacterial DNA. Recently, several structurally distinct types of CpG ODN were identified that differentially activate human immune cells. These ODNs may be useful as vaccine adjuvants, anti-allergens and in the treatment of infectious diseases and ...
Corrosion behaviours of Ti6Al4V-Mg/Mg-Alloy composites ESEN, ZİYA; Ocala, Ezgi Butev; Akkaya, Asli; Gurcay, Bensu; Ozcan, Ceren; Ozgumus, Burcu Asli; Duygulu, Ozgur; Dericioğlu, Arcan Fehmi (Elsevier BV, 2020-04-15) The effect of coupling of unalloyed Mg and Mg-alloys (AZ91 and WE43) with Ti6Al4V alloy on corrosion and degradation behaviours of produced composites has been investigated in simulated body fluid (SBF) by hydrogen evolution, and surface and electrochemical characterization techniques. Combining of unalloyed Mg with Ti6Al4V intensified galvanic corrosion and catastrophic failure occurred by initiation of microcracks formed by sudden hydrogen gas evolution. In contrast to other composites, Ti6Al4V-AZ91 compo...
Immunoadjuvant action of plasmid DNA in liposomes Gürsel, Mayda; Ozkan, M; Özcengiz, Gülay (1999-03-17) Bacterial DNA and oligodeoxynucleotides containing immunostimulatory sequences with a CpG motif stimulated a Th1 type response in vivo. The adjuvant action of a non-coding plasmid DNA derived from pRc/CMV HBS (encoding the S region of hepatitis B surface antigen, HBsAg) in mice was investigated. The role of methylation on the adjuvanticity of the plasmid as well as the effect of vaccine formulation employed on the outcome of antigen-specific humoral and cellular responses were also studied. The results demo...
SORPTION PROPERTIES OF SILICALITE-1 OF PURE SILICA FORM - THE INFLUENCE OF SORPTION HISTORY ON SORPTION KINETICS OF CRITICALLY SIZED MOLECULES KARSH, H; Çulfaz, Ali; YUCEL, H (Elsevier BV, 1992-07-01) Sorption properties of silicalite-1 samples of pure silica form for some parafinic and aromatic hydrocarbons of different molecular sizes were investigated. It was observed that sorption rates and apparent equilibrium capacities for critically sized molecules, m-xylene and o-xylene, depend on the sorption history of the sample. Sorption of m- and o-xylene proceeded extremely slowly on fresh samples of silicalite-1, whereas sorption rates of these molecules on silicalite-1 samples that had passed through a p...

Citation Formats

F. Takeshita, I. Gursel, K. Ishii, K. Suzuki, M. Gürsel, and D. Klinman, “Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.,” Seminars in immunology, pp. 17–22, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40127.