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Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.
Date
2004-02-01
Author
Takeshita, F
Gursel, I
Ishii, KJ
Suzuki, K
Gürsel, Mayda
Klinman, DM
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.
Subject Keywords
CpG DNA
,
TLR 9
,
PAMP
,
Signal transduction
URI
https://hdl.handle.net/11511/40127
Journal
Seminars in immunology
DOI
https://doi.org/10.1016/j.smim.2003.10.009
Collections
Department of Biology, Article
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F. Takeshita, I. Gursel, K. Ishii, K. Suzuki, M. Gürsel, and D. Klinman, “Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.,”
Seminars in immunology
, pp. 17–22, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40127.