Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.

Date

2004-02-01

Author

Takeshita, F
Gursel, I
Ishii, KJ
Suzuki, K
Gürsel, Mayda
Klinman, DM

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Synthetic oligodeoxynucleotides (ODN) expressing non-methylated "CpG motifs" patterned after those present in bacterial DNA have characteristic immunomodulatory effects. CpG DNA is recognized as a pathogen-associated molecular pattern, and triggers a rapid innate immune response. CpG ODN are being harnessed for a variety of therapeutic uses, including as immune adjuvants, for cancer therapy, as anti-allergens, and as immunoprotective agents. The signal transduction pathway mediated by the engagement of CpG DNA with Toll-like receptor 9 (TLR9) is shared with other members of the TLR family. Recent studies demonstrate that formation and maturation of CpG DNA-containing endosomes are regulated by phosphatidylinositol 3 kinases and the Ras-associated GTP-binding protein, Rab5, which are essential for the initiation of TLR9-mediated signaling.

Subject Keywords

CpG DNA, TLR 9, PAMP, Signal transduction

URI

https://hdl.handle.net/11511/40127

Journal

Seminars in immunology

DOI

https://doi.org/10.1016/j.smim.2003.10.009

Collections

Department of Biology, Article

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Citation Formats

F. Takeshita, I. Gursel, K. Ishii, K. Suzuki, M. Gürsel, and D. Klinman, “Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9.,” Seminars in immunology, pp. 17–22, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/40127.