Synthesis of various camphor-based chiral pyridine derivatives

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2005

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Işık, Murat

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Chiral aromatic nitrogen heterocycles are finding many applications in asymmetric organic synthesis, particularly as ligands in the preparation of chiral metal complexes. Since camphor-based chiral auxiliaries are known to be especially effective, a number of pyridines fused to the camphor skeleton have been reported. It is well known that nicotinic acid and its derivatives exhibiting qualitatively the biological activity of nicotinamide, which acts as an electron acceptor in many biological redox reactions. In connection to our works, we attempted to develop short and convenient way to prepare various camphorderived chiral pyridine or nicotinic acid derivatives. Here we report our results obtained from the annulation of (+)- b- hydroxymethylenecamphor as the feasible chiral pool with various enamines derived from active methylene compounds. (+)- b- Hydroxymethylenecamphor prepared from cheap and easily available natural (+)-camphor and enamines were transformed into chiral camphor-based pyridine derivatives via tandem condensation reaction in good yields.

Subject Keywords

Chemistry, Organic

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http://etd.lib.metu.edu.tr/upload/12605824/index.pdf
https://hdl.handle.net/11511/14616

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

M. Işık, “Synthesis of various camphor-based chiral pyridine derivatives,” M.S. - Master of Science, Middle East Technical University, 2005.