Bivariate random effects and hierarchical meta-analysis of summary receiver operating characteristic curve on fine needle aspiration cytology

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2011

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Erte, İdil

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In this study, meta-analysis of diagnostic tests, Summary Receiver Operating Characteristic (SROC) curve, bivariate random effects and Hierarchical Summary Receiver Operating Characteristic (HSROC) curve theories have been discussed and accuracy in literature of Fine Needle Aspiration (FNA) biopsy that is used in the diagnosis of masses in breast cancer (malignant or benign) has been analyzed. FNA Cytological (FNAC) examination in breast tumor is, easy, effective, effortless, and does not require special training for clinicians. Because of the uncertainty related to FNAC‘s accurate usage in publications, 25 FNAC studies have been gathered in the meta-analysis. In the plotting of the summary ROC curve, the logit difference and sums of the true positive rates and the false positive rates included in the meta-analysis‘s codes have been generated by SAS. The formula of the bivariate random effects model and hierarchical summary ROC curve is presented in context with the literature. Then bivariate random effects implementation with the new SAS PROC GLIMMIX is generated. Moreover, HSROC implementation is generated by SAS PROC HSROC NLMIXED. Curves are plotted with RevMan Version 5 (2008). It has been stated that the meta-analytic results of bivariate random effects are nearly identical to the results from the HSROC approach. The results achieved through both random effects meta-analytic methods prove that FNA Cytology is a diagnostic test with a high level of distinguish over breast tumor.

Subject Keywords

Breast, Privacy, Right of.

URI

http://etd.lib.metu.edu.tr/upload/12613619/index.pdf
https://hdl.handle.net/11511/20958

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Graduate School of Informatics, Thesis

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Citation Formats

İ. Erte, “Bivariate random effects and hierarchical meta-analysis of summary receiver operating characteristic curve on fine needle aspiration cytology,” M.S. - Master of Science, Middle East Technical University, 2011.