Synthesis of Iodo-substituted spiro-fused pyridine derivatives

Download

index.pdf

Date

2014

Author

Teke, Ecem

Metadata

Show full item record

Item Usage Stats

151
views

115
downloads

Spiro cyclic molecules have gained significance because of their biological activities and electronic properties. Spiro frameworks are present in importance natural products and optoelectronic materials. Moreover, due to steric strain, the presence of a spiro carbon atom induces easy rearrangements that can lead to diﬀerent cyclic products. Although there are some methods to synthesize spiro compounds, the synthesis of iodo-substituted spiro-fused pyridines have not been studied. Accordingly, in this thesis, a new method for the synthesis of iodo-substituted spiro-fused pyridines have been developed via electrophilic cyclizations. After preparation of 5-alkynyl-4-(4-methoxyphenyl)pyridines, these derivatives were subjected to electrophilic cyclization in the presence of moleculer iodine and NaHCO3, which afforded iodo-substituted spiro-fused pyridines. The reaction conditions have been optimized and the limitations, scope and mechanism of these cyclizations have been studied.

Subject Keywords

Pyridine., Iodides., Electrophiles., Pyridine, Spiro compound.

URI

http://etd.lib.metu.edu.tr/upload/12616813/index.pdf
https://hdl.handle.net/11511/23301

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Synthesis of pyrroloquinoxalino-fused benzoxazepines and ester-containing iodopyridines Yazıcı, Nuray Esra; Zora, Metin; Department of Chemistry (2013) Heterocyclic fused compounds have gained considerable attention for pharmaceutical applications since they show remarkable biological activities such as antitumor and/or anticancer activities. In particular, the synthesis of seven-membered ring embedded molecules is a challenging issue among organic chemists. Therefore, we have aimed to develop one-pot reaction for the synthesis of seven-membered-fused heterocyclic compounds. We have developed a new methodology for the synthesis of pyrrolo[2',1':3,4]quinoxa...
Preparation and thermal characterization of poly(2-vinylpyridine) copolymers coordinated to Cr nanoparticles Öztürk, Yurdagül; Kayran, Ceyhan; Hacaloğlu, Jale (2015-06-01) In this study, polystyrene-block-poly(2-vinylpyridine), PS-b-P2VP, polyisoprene-block-poly(2-vinylpyridne), PI-b-P2VP and poly(methyl metacrylate)-block-poly(2-vinylpyridine), PMMA-b-P2VP, coordinated to Cr metal were synthesized and characterized by Fourier transform infrared, transmission electron microscopy and direct pyrolysis mass spectrometry techniques. Both thermal degradation mechanism and thermal stability of P2VP blocks were affected by the coordination of Cr nanoparticles to nitrogen of pyridine...
Synthesis, crystal structure, spectroscopic investigations, thermal behavior and DFT calculations of pentacarbonyl(2-methylpyrazine)chromium(0) MORKAN, İzzet; Celik, Derya; Morkan, Ayse Uztetik; GÜVEN, KUTALMIŞ (2012-07-01) Pentacarbonyl(2-methylpyrazine)chromium(0) [Cr(CO)(5)(2mpyz)], complex was isolated from its n-hexane solution as orange plate-like crystals which were characterized by IR, NMR spectroscopies and X-ray crystallography. The crystallographic results show that the complex was crystallized in the monoclinic system with the unit cell parameters of a = 7.176 (5), b = 12.045 (3), c = 14.461 (3)angstrom, beta=90.44 (3)degrees and space group 2/M. The single crystal structure of the complex shows the bonding of chro...
Oligomerization and cell surface expression of recombinant GABA(A) receptors tagged in the delta subunit Oflaz, Furkan Enes; Son, Çağdaş Devrim; Arslan, Ayla (IMR Press, 2019-12-01) The gamma-Aminobutyric acid type A receptors (GABA(A) Rs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain. Studies have shown the expression of recombinant GABA(A) R subunits tagged with the green fluorescent protein (GFP), a 26.9 kDa protein that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. This allows the formation of recombinant proteins essential for the development of relevant in-vitro and in-vivo methodologi...
Synthesis, structural and magnetic characterization of soft magnetic nanocrystalline ternary FeNiCo particles Toparlı, Çiğdem; Gürmen, Sebahattin (2017-02-01) The present study focuses on the synthesis, microstructural and magnetic properties of ternary FeNiCo nanoparticles. Nanocrystalline ternary FeNiCo particles were synthesized via hydrogen reduction assisted ultrasonic spray pyrolysis method in single step. The effect of precursor concentration on the morphology and the size of particles was investigated. The syntheses were performed at 800 degrees C. Structure, morphology and magnetic properties of the as-prepared products were characterized through X-ray d...

Citation Formats

E. Teke, “Synthesis of Iodo-substituted spiro-fused pyridine derivatives,” M.S. - Master of Science, Middle East Technical University, 2014.