Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Frequently Asked Questions
Frequently Asked Questions
Communities & Collections
Communities & Collections
A multi-layered graphical model of the relation among SNPS, GENES, and pathways based on subgraph search
Download
index.pdf
Date
2015
Author
Ersoy, Gökhan
Metadata
Show full item record
Item Usage Stats
2
views
1
downloads
The analysis of Single Nucleotide Polymorphisms (SNPs) through Genome Wide Association Studies (GWAS) presents great potential for describing disease loci and gaining insight into the underlying etiology of diseases. Recently described combined p-value approach allows identification of associations at gene and pathway level. The integrated programs like METU-SNP produce simple lists of either SNP id/gene id/pathway title and their p-values and significance status or SNP id/disease id/pathway information. In this study, starting with the SNP id, we have annotated related gene ids and pathway ids consecutively. Then we have computed the intersection of these pathways, and visualized the common sub-graphs by an interactive graphical library. The tool developed in this thesis provides a visualization of the text output as graphical knowledge networks; hence, facilitates the efficient use of the information offered by the candidate SNP Biomarkers and helping discovery of SNP associated biological networks
Subject Keywords
Genetic markers.
,
Biochemical markers.
,
Genetic polymorphisms.
,
Single nucleotide polymorphisms.
URI
http://etd.lib.metu.edu.tr/upload/12618923/index.pdf
https://hdl.handle.net/11511/24740
Collections
Graduate School of Informatics, Thesis