Enantiomeric resolution of racemic secondary N-methyl-2-pyrrolyl carbinols by Candida Cylindracea Lipase (CCL)

Download

093092.pdf

Date

2000

Author

Başyiğit, Esra

Metadata

Show full item record

Item Usage Stats

41
views

0
downloads

URI

https://hdl.handle.net/11511/2636

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Enantiomeric resolution of racemic tertiary 1-methyl-2-pyrrolylcarbinols by candida cylindracea lipase (CCL) Elmalı, Olcay; Tanyeli, Cihangir; Balcı, Metin; Department of Chemistry (2000)
Enantiomeric resolution of racemic 2-furylcarbinols by pig liver esterase (PLE) Arkın, Ali Hakan; Tanyeli, Cihangir; Department of Chemistry (1997)
Enantioselective biotransformation of acetoxy ketones to chiral alfa-hydroxy derivatives by using Rhizopus Oryzae Doğanel, Fatoş; Demir, Ayhan S.; Department of Biotechnology (1997)
Enantiomeric resolution of (+-)-2-substituted norbornadiene and perchloro norbornadiene derivatives via hydrolase type enzymes Çelikel, Gamze; Tanyeli, Cihangir; Ahmedov, İdris Mecitoğlu; Department of Chemistry (2000)
Enantioselective formal synthesis of pregabalin with bifunctional acid/base organocatalysts Kapucu, Merve; Tanyeli, Cihangir; Department of Chemistry (2013) Pregabalin, which is marketed under the brand name of Lyrica by Pfizer, is an important chiral drug in the treatment of epilepsy and neuropathic pain. Since only S-Pregabalin is active for the treatment, asymmetric synthesis was accomplished in 6 steps and the chiral induction was done by transition metal catalysis in industrial production. In this thesis, we applied an alternative synthetic route taken place in 3 steps. The key step comprised the chiral induction done by organocatalysis and the formal asym...

Citation Formats

E. Başyiğit, “Enantiomeric resolution of racemic secondary N-methyl-2-pyrrolyl carbinols by Candida Cylindracea Lipase (CCL),” Middle East Technical University, 2000.