Enantiomeric resolution of (+-)-2-substituted norbornadiene and perchloro norbornadiene derivatives via hydrolase type enzymes

Çelikel, Gamze


Enantiomeric separation of various cyclic a'-Acetoxyenones via hydrolase type enzymes
Dikici, Emre; Tanyeli, Cihangir; Department of Chemistry (1997)
Enantioselective reduction of ketones with borane catalyzed by cyclic β- amino alcohols prepared from proline
Demir, Ayhan S; Mecitoglu, Idris; Tanyeli, Cihangir; Gülbeyaz, Volkan (Elsevier BV, 1996-12)
New catalysts have been prepared from (S)- and (R)- proline and the asymmetric borane reduction of prochiral ketones using these catalysts has been studied. The secondary alcohols were obtained in 76-95% yield with 57-96% enantiomeric excesses. Copyright (C) 1996 Elsevier Science Ltd
Enantioselective synthesis of 4,5,6,7-tetrahydro-4-oxo-benzofuran-5-yl acetate and 1-benzyl-4,5,6,7-tetrahydro-4-oxo-1(H)-indol-5-yl acetate using chemoenzymatic methods
Demir, Ayhan Sıtkı; Caliskan, Zerrin; Sahin, Ertan (Elsevier BV, 2007-03-01)
The chemoenzymatic synthesis of both of the enantiomers of pharmacologically interesting compounds such as 4,5,6,7-tetrahydro-4-oxobenzofuran-5-yl acetate (2a), 4,5,6,7-tetrahydro-4-oxo-6,6-dimethylbenzofuran-5-yl acetate (2b), and their hydroxy derivatives 3a, 3b, 1-benzyl4,5,6,7-tetrahydro-4-oxo-1(H)-indol-5-yl acetate (5), starting from 6,7-dihydrobenzofuran-4(5H)-one (la), 6,7-dihydro-6,6-dimethylbenzofuran4(5H)-one (7b), and 1-benzyl-6,7-dihydro-1 H-indol-4(5H)-one (4) are reported. Manganese(III) acet...
Enantioselective synthesis of (S)-2-hydroxypropanone derivatives by benzoylformate decarboxylase catalyzed C-C bond formation
Dunnwald, T; Demir, Ayhan Sıtkı; Siegert, P; Pohl, M; Muller, M (2000-06-01)
Chiral 2-hydroxypropanone derivatives 5a-v, 8a-d, and 10a, b were formed by benzoylformate decarboxylase (BFD) catalyzed C-C bond formation. A donor aldehyde and acetaldehyde as an acceptor were carboligated in aqueous buffer solution with remarkable ease in high chemical yield and good to high optical purity. The substrate range of this thiamin diphosphate dependent enzyme was examined to employ this benzoin condensation type reaction in stereoselective synthesis. The observed dependence of the enantiomeri...
Enantiomeric resolution of racemic tertiary 1-methyl-2-pyrrolylcarbinols by candida cylindracea lipase (CCL)
Elmalı, Olcay; Tanyeli, Cihangir; Balcı, Metin; Department of Chemistry (2000)
Citation Formats
G. Çelikel, “Enantiomeric resolution of (+-)-2-substituted norbornadiene and perchloro norbornadiene derivatives via hydrolase type enzymes,” Middle East Technical University, 2000.