Department of Chemistry
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Synthesis, molecular modeling, DFT studies, and EPR analysis of 1,4-dihydropyridines as potential calcium channel blockers
KOÇAK ASLAN, EBRU; Lam, Kevin; Dengiz, Çağatay; Denzinger, Katrin; Dicle Erdamar, Isık Yesim; Huang, Sun; Zamponi, Gerald W.; Wolber, Gerhard; GÜNDÜZ, MİYASE GÖZDE (2024-07-05)
1,4-Dihydropyridines (DHPs) are widely recognized as a highly effective class of L-type calcium channel blockers that offer significant therapeutic potential in managing cardiovascular conditions. Furthermore, their abilit...
1,3‐Diynes as Precursors for the Synthesis of Triazene‐ and Diethylaniline‐Bearing Push‐Pull NLOphores
Inyurt, Fevzi Can; Dengiz, Çağatay (2024-02-01)
Withinthe scopeof this study,a total of eight new NLOphoresof the D-π-A-π-Dtype have been synthesized.This was achievedby applyingclick-type[2+2] cycloaddition-retroelectrocycliza-tion reactionsof unsymmetrical1,3-diyneswi...
Click-Type Synthesis of Homoconjugated Push-Pull Chromophores: Computational Investigation of Optical and Nonlinear Optical (NLO) Properties
Inyurt, Fevzi Can; Mammadova, Flora; Dengiz, Çağatay (2023-1-01)
Homoconjugated push-pull chromophores were obtained by an efficient, click-type formal [2+2] cycloaddition. With these short synthetic transformations, complex chromophore structures were achieved in a single step without ...
Cyano-rich donor-acceptor-donor-type NLOphores containing dialkylated triazene and aniline groups*
Mammadova, Flora; Inyurt, Fevzi Can; Barsella, Alberto; Dengiz, Çağatay (2023-01-01)
Continuous progress on the synthesis of push-pull chromophores is related to their outstanding optoelectronic properties. Expanding scope is a challenge due to the instability of targets and long synthetic strategies. Here...
Evaluation of the effect of graphene oxide-based nanocomposites on smear layer by a scanning electron microscope: Laboratory investigation
Sehitoglu, Gulbin; Cakici, Fatih; Soylemez, Saniye; Dengiz, Çağatay (2023-01-01)
This study is to examine the effect of graphene oxide (GO) and GO-based nanocomposites (GO_EDTA, GO_CHIT) on the smear layer by scanning electron microscopy (SEM). Sixty human single-rooted anterior teeth were used. Sample...
Biphenylene-containing polycyclic conjugated compounds
Dengiz, Çağatay (2023-01-01)
There has been a growing emphasis on the synthesis of polycyclic conjugated compounds, driven by their distinct structural characteristics that make them valuable candidates for use in cutting-edge technologies. In particu...
Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity
KOÇAK ASLAN, EBRU; HAN, MUHAMMED İHSAN; Krishna, Vagolu Siva; Tamhaev, Rasoul; Dengiz, Çağatay; DOĞAN, ŞENGÜL DİLEM; Lherbet, Christian; Mourey, Lionel; Tonjum, Tone; GÜNDÜZ, MİYASE GÖZDE (2022-10-01)
Isoniazid (INH) is one of the key molecules employed in the treatment of tuberculosis (TB), the most deadly infectious disease worldwide. However, the efficacy of this cornerstone drug has seriously decreased due to emergi...
3-Alkynylindoles as Building Blocks for the Synthesis of Electronically Tunable Indole-Based Push-Pull Chromophores.
ERDEN, KÜBRA; Dengiz, Çağatay (2022-03-18)
© 2022 American Chemical Society.In this study, two different classes of push-pull chromophores were synthesized in modest to excellent yields by formal [2+2] cycloaddition-retroelectrocyclization (CA-RE) reactions. N-Meth...
Isoquinolinedione-urea hybrids: Synthesis, antibacterial evaluation, drug-likeness, molecular docking and DFT studies
In the present study, we applied the molecular hybridization approach to combine isoquinolinedione and urea pharmacophores in the same molecules. The hybrid compounds (IU1-IU14) were obtained by the reaction of 2-aminohomo...
Attaching azoles to Hantzsch 1,4-dihydropyridines: Synthesis, theoretical investigation of nonlinear optical properties, antimicrobial evaluation and molecular docking studies
GÜNDÜZ, MİYASE GÖZDE; Dengiz, Çağatay; KOÇAK ASLAN, EBRU; Skaro Bogojevic, Sanja; Nikodinovic-Runic, Jasmina (2022-01-05)
In the present study, we designed three novel compounds via the combination of two precious nitrogen-containing scaffolds; 1,4-dihydropyridine (DHP) and azole, in the same molecule. To synthesize the title compounds, initi...
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