Rengül Atalay

E-mail

rengul@metu.edu.tr

Department

Graduate School of Informatics

ORCID

0000-0003-2408-6606

Scopus Author ID

6602870986

Web of Science Researcher ID

F-5780-2013

Drug Repurposing Approach to Identify Candidate Drug Molecules for Hepatocellular Carcinoma Baser, Tugce; Rifaioğlu, Ahmet Süreyya; Atalay, Mehmet Volkan; Atalay, Rengül (2024-09-01) Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, with a high mortality rate due to the limited therapeutic options. Systemic drug treatments improve the patient’s life expectancy by only a few mon...
Network-based in silico modeling for drug repurposing and in vitro validation in hepatocellular carcinoma Sinoplu, Esra; Tunçbağ, Nurcan; Atalay, Rengül (2022-10-25)
Synthesis and Biological Evaluation of Novel Isoxazole-Piperazine Hybrids as Potential Anticancer Agents with Inhibitory Effects on Liver Cancer Stem Cells İbiş, Kübra; Sinoplu, Esra; Çalışkan, Burcu; Atalay, Rengül; Banoğlu, Erden (2022-08-29)
BAZI VİSİNAL DİARİL HETEROSİKLİK BİLEŞİKLERİN ANTİKANSER AKTİVİTELERİNİN ARAŞTIRILMASI Turanlı, Sümeyye; Sinoplu, Esra; Akhan Güzelcan, Ece; Atalay, Rengül; Çalışkan, Burcu; Banoğlu, Erden (2022-08-26)
Identification of undefined off-targets of novel drugs and drug combinations with network-based in silico modeling and in vitro validation in hepatocellular carcinoma Sinoplu, Esra; Tunçbağ, Nurcan; Atalay, Rengül (2022-06-24) Introduction Hepatocellular carcinoma (HCC) is one of the most common and deadliest cancer worldwide. It is highly resistant to conventional chemotherapies due to the hyperactivation of many critical survival signaling ...
Anticancer activity of novel vicinal diaryl isoxazole compounds in hepatocellular carcinoma Sinoplu, Esra; Akhan Güzelcan, Ece; Turanlı, Sümeyye; Lengerli, Deniz; Çalışkan, Burcu; Banoğlu, Erden; Atalay, Rengül (2022-02-04) Background and Aims Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and 2nd lethal cancer in the world. The global burden of HCC is expected to increase in the next decade due to the increa...
DeepDistance: A multi-task deep regression model for cell detection in inverted microscopy images Koyuncu, Can Fahrettin; Gunesli, Gozde Nur; Atalay, Rengül; GÜNDÜZ DEMİR, Çiğdem (Elsevier BV, 2020-07-01) This paper presents a new deep regression model, which we call DeepDistance, for cell detection in images acquired with inverted microscopy. This model considers cell detection as a task of finding most probable locations ...
Design, Synthesis and In Vitro Cytotoxic Activity of New 6,9-Disubstituted Purine Analogues Kucukdumlu, Asligul; TUNÇBİLEK, MERAL; GÜVEN, EBRU BİLGET; Atalay, Rengül (2020-01-01) A series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds (7-26) were screened initially fo...
Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening Ozgencil, Fikriye; EREN, GÖKÇEN; ÖZKAN, YEŞİM; GÜNTEKİN ERGÜN, SEZEN; Atalay, Rengül (Elsevier BV, 2020-01-01) Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide (NAM) with 5-phosphoribosyl-1-prophosphate (PRPP) to yield nicotinamide mononucleotide (NMN), a rate limiting enzyme in a mammalian ...
A NEW THIADIAZINE DERIVATIVE INDUCES OXIDATIVE STRESS DEPENDENT CELL DEATH IN HEPATOCELLULAR CARCINOMA STEM CELLS Kahraman, Deniz Cansen; Aytac, Peri; TOZKOPARAN KÖPRÜCÜ, BİRSEN; Atalay, Rengül (2019-10-01)

Citation Formats