Salih Özçubukçu

E-mail

osalih@metu.edu.tr

Department

Department of Chemistry

ORCID

0000-0001-5981-1391

Scopus Author ID

6506234966

Web of Science Researcher ID

P-8940-2019

Human estrogen receptor alpha (ERα) targeted cyclic peptides inhibit cell growth and induce apoptosis in MCF-7 cells ŞENTÜRK, HAKAN; Dedeakayoğulları, Huri; Marion, İlke U.; Özçubukçu, Salih; Kesici, Mehmet Seçkin; Beyge, Şeyma Ünsal; Acar, Muradiye; Genel, Merve Erkısa; AKBAŞ, FAHRİ; Ulukaya, Engin (2024-08-01) Objectives: Human estrogen receptor alpha (ERα) is considered an important target, especially in the treatment of breast cancer, as it has a vital role in cancer development. ERα-targeted therapies generally target the lig...
Rational Design of an Acceptor-Chromophore-Relay-Catalyst Tetrad Assembly for Water Oxidation Chalil Oglou, Ramadan; Ulusoy Ghobadi, Turkan Gamze; Saylam, Aytul; Bese, Damla; Bese, Cagri; Yaglioglu, Gul; Özçubukçu, Salih; Ozbay, Ekmel; Karadas, Ferdi (2024-01-01) We report the step-by-step synthesis of a precious metal-free acceptor-chromophore-relay-catalyst tetrad assembly that exhibits a turnover frequency (TOF) of 7.5 × 10−3 s−1 under neutral conditions. Transient absorption sp...
Fullerene-based mimics of enhanced acetylcholine detection for the diagnosis of Alzheimer's disease Soylemez, Saniye; Dolgun, Volkan; Özçubukçu, Salih (2023-10-01) The design of sensitive and cost-effective enzyme-free sensor systems for the effective electrooxidation of acetylcholine (ACh) plays a key role in following up on Alzheimer's disease. We report a fullerenzyme-based cataly...
Tetraphenyl-1,4-dioxin and Tetraphenyl-pyrane-4-one: Old Molecules, New Insights Soydan, Medine; Okyar, Burcu; ZORLU, YUNUS; Marıon, Antoıne; Özçubukçu, Salih (2023-05-01) Aggregation-induced emission (AIE) is a phenomenon wherecertainmolecules or materials become highly luminescent when they aggregateor come together in a condensed state, such as a solid or a solution.Moreover, new molecule...
A Novel PEtOx-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery Gülyüz, Sevgi; SESSEVMEZ, Melike; Ukuser, Gokcen; Khalily, Melek Parlak; Tiryaki, Selen; Sipahioglu, Tarik; Birgül, Kaan; Ömeroğlu, İpek; Özçubukçu, Salih; Telci, Dilek; Küçükgüzel, Ş. Güniz; Durmuş, Mahmut; Cevher, Erdal; Yılmaz, Özgür (2023-01-01) This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using ...
Highly Potent Peptide Therapeutics To Prevent Protein Aggregation in Huntington’s Disease Khan, Anooshay; Özçelik, Cemile Elif; Begli, Ozge; Oguz, Oguzhan; Kesici, Mehmet Seçkin; Kasırga, Talip Serkan; Özçubukçu, Salih; YÜCA YILMAZ, Esra; Seker, Urartu Ozgur Safak (2023-01-01) Huntington’s disease (HD) is a neurodegenerative disorder resulting from a significant amplification of CAG repeats in exon 1 of the Huntingtin (Htt) gene. More than 36 CAG repeats result in the formation of a mutant Htt (...
Downstream signalling of the disease-associated mutations on GPR56/ADGRG1 CEVHEROĞLU, ORKUN; Demir, Nil; Kesici, Mehmet Seçkin; Özçubukçu, Salih; Son, Çağdaş Devrim (2023-01-01) GPR56/ADGRG1 is an adhesion G protein-coupled receptor (GPCR) and mutations on this receptor cause cortical malformation due to the over-migration of neural progenitor cells on brain surface. At pial surface, GPR56 interac...
Nanoarchitectonics of Fullerene-Based Enzyme Mimics for Osteogenic Induction of Stem Cells. Yeniterzi, Dilara; Demirsoy, Zeynep; Saylam, Aytül; Özçubukçu, Salih; Gülseren, Gülcihan (2022-06-25)
Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity. Gülseren, Gülcihan; Saylam, Aytül; Marıon, Antoıne; Özçubukçu, Salih (2021-09-29) The design of catalysts with greater control over catalytic activity and stability is a major challenge with substantial impact on fundamental chemistry and industrial applications. Due to their unparalleled diversity, sel...
Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(epsilon-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity Gulyuz, Sevgi; Ozkose, Umut Ugur; Khalily, Melek Parlak; Kesici, Mehmet Seçkin; Kocak, Polen; Bolat, Zeynep Busra; Kara, Aslı; Öztürk, Naile; Özçubukçu, Salih; Bozkır, Asuman; Alptürk, Onur; Telci, Dilek; Şahin, Fikrettin; Vural, Imran; Yilmaz, Ozgur (2021-07-01) Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting...

Citation Formats