Salih Özçubukçu

E-mail

osalih@metu.edu.tr

Department

Department of Chemistry

ORCID

0000-0001-5981-1391

Scopus Author ID

6506234966

Web of Science Researcher ID

P-8940-2019

Liquid Crystals that Respond to the Aqueous Phase Reactions Catalyzed by Synthetic Enzyme Mimics Karaman, Deniz; Saylam, Aytul; Akar, Elif; Özçubukçu, Salih; Büküşoğlu, Emre (2025-09-15) Liquid crystal (LC)-aqueous soft interface sensors have shown potential toward a wide range of analytes, which also include tracking of their reactions. While these sensors have shown promise in studying enzymatic activity...
Synthesis and design of functional fullerenol-based electrochemical nanobiosensor to examine the inhibition effects of anti-Alzheimer drug active pyridostigmine on acetylcholinesterase Soyler, Dilek; Dolgun, Volkan; KURBANOĞLU, SEVİNÇ; Özçubukçu, Salih; Soylemez, Saniye (2025-09-01) Glutamic acid functionalized fullerenol (F-Glu) based electrochemical AChE enzyme biosensor (GE/F-Glu/AChE) was utilized for the detection of acetylthiocholine chloride and pyridostigmine for the first time. The performanc...
Surface Engineering of MXene and Functional Fullerenols for Cancer Biomarker ‘eIF3d’ Soyler, Dilek; Dolgun, Volkan; Çetin, Kemal Önder; Khan, Yaqoob; Guler Celik, Emine; Özçubukçu, Salih; Ünalan, Hüsnü Emrah; Timur, Suna; Soylemez, Saniye (2025-03-01) Selective and sensitive detection of eIF3d (eukaryotic translation initiation factor 3 complex, subunit D), a protein biomarker, is of fundamental significance for the diagnosis of various cancers. Here, we report an elect...
A Heterodox Approach for Designing Iron Photosensitizers: Pentacyanoferrate(II) Complexes with Monodentate Bipyridinium/Pyrazinium-Based Acceptor Ligands Schmidt, Heiner; Oglou, Ramadan C.; Tunçer, Hüseyin O.; Ghobadi, Turkan G. U.; Tekir, Şafak; Sertcelik, Kubra N. O.; Ibrahim, Abdelrahman; Döhler, Lotta; Özçubukçu, Salih; Kupfer, Stephan; Dietzek-Ivanšić, Benjamin; Karadaş, Ferdi (2025-01-01) The main obstacle in replacing well-established precious ruthenium photosensitizers with earth-abundant iron analogs is the short excited state lifetimes of metal-to-ligand charge transfer (MLCT) states due to relatively w...
Application of Redox-Responsive Cysteine-Based Organogels as a Drug Delivery System for Doxorubicin Zare, Diba; Yilmaz, Gamze; Özçubukçu, Salih (2024-12-25) Cysteine derivatives having disulfide bonds in their side chains can be used as redox-responsive organogelators. The disulfide bond can be cleaved in the presence of certain reducing agents like thiol derivatives such as g...
Human estrogen receptor alpha (ERα) targeted cyclic peptides inhibit cell growth and induce apoptosis in MCF-7 cells ŞENTÜRK, HAKAN; Dedeakayoğulları, Huri; Marion, İlke U.; Özçubukçu, Salih; Kesici, Mehmet Seçkin; Beyge, Şeyma Ünsal; Acar, Muradiye; Genel, Merve Erkısa; AKBAŞ, FAHRİ; Ulukaya, Engin (2024-08-01) Objectives: Human estrogen receptor alpha (ERα) is considered an important target, especially in the treatment of breast cancer, as it has a vital role in cancer development. ERα-targeted therapies generally target the lig...
Rational Design of an Acceptor-Chromophore-Relay-Catalyst Tetrad Assembly for Water Oxidation Chalil Oglou, Ramadan; Ulusoy Ghobadi, Turkan Gamze; Saylam, Aytul; Bese, Damla; Bese, Cagri; Yaglioglu, Gul; Özçubukçu, Salih; Ozbay, Ekmel; Karadas, Ferdi (2024-01-01) We report the step-by-step synthesis of a precious metal-free acceptor-chromophore-relay-catalyst tetrad assembly that exhibits a turnover frequency (TOF) of 7.5 × 10−3 s−1 under neutral conditions. Transient absorption sp...
Fullerene-based mimics of enhanced acetylcholine detection for the diagnosis of Alzheimer's disease Soylemez, Saniye; Dolgun, Volkan; Özçubukçu, Salih (2023-10-01) The design of sensitive and cost-effective enzyme-free sensor systems for the effective electrooxidation of acetylcholine (ACh) plays a key role in following up on Alzheimer's disease. We report a fullerenzyme-based cataly...
Tetraphenyl-1,4-dioxin and Tetraphenyl-pyrane-4-one: Old Molecules, New Insights Soydan, Medine; Okyar, Burcu; ZORLU, YUNUS; Marıon, Antoıne; Özçubukçu, Salih (2023-05-01) Aggregation-induced emission (AIE) is a phenomenon wherecertainmolecules or materials become highly luminescent when they aggregateor come together in a condensed state, such as a solid or a solution.Moreover, new molecule...
Highly Potent Peptide Therapeutics To Prevent Protein Aggregation in Huntington’s Disease Khan, Anooshay; Özçelik, Cemile Elif; Begli, Ozge; Oguz, Oguzhan; Kesici, Mehmet Seçkin; Kasırga, Talip Serkan; Özçubukçu, Salih; YÜCA YILMAZ, Esra; Seker, Urartu Ozgur Safak (2023-01-01) Huntington’s disease (HD) is a neurodegenerative disorder resulting from a significant amplification of CAG repeats in exon 1 of the Huntingtin (Htt) gene. More than 36 CAG repeats result in the formation of a mutant Htt (...

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