Salih Özçubukçu

Department of Chemistry
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Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer
Nezir, Ayca Ece; PARLAK KHALİLY, MELEK; Gulyuz, Sevgi; Özçubukçu, Salih; KÜÇÜKGÜZEL, ŞÜKRİYE GÜNİZ; Yilmaz, Ozgur; TELCİ, DİLEK (2021-04-01)
High toxicity caused by chemotherapeutic drugs and the acquisition of drug resistance by cancer cells are the major drawbacks in cancer therapy. A promising approach to overcome the posed barriers is conjugating tumor-homi...
A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes
Oz, Umut Can; Bolat, Zeynep Busra; Ozkose, Umut Ugur; Gulyuz, Sevgi; Kucukturkmen, Berrin; Khalily, Melek Parlak; Özçubukçu, Salih; Yilmaz, Ozgur; Telci, Dilek; ESENDAĞLI, GÜNEŞ; Sahin, Fikrettin; Bozkir, Asuman (2021-04-01)
© 2021 Elsevier B.V.The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue-specific targeting, therefore the optimization of the targeted nanoparticles is a key fac...
The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
Ozkose, Umut Ugur; Gulyuz, Sevgi; Parlak Khalily, Melek; Özçubukçu, Salih; BOZKIR, ASUMAN; TAŞDELEN, MEHMET ATİLLA; Alptürk, Onur; Yilmaz, Ozgur (2020-11-01)
To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these syst...
Synthesis, biocompatibility and gene encapsulation of poly(2-Ethyl 2-Oxazoline)-dioleoyl phosphatidylethanolamine (PEtOx-DOPE) and post-modifications with peptides and fluorescent dye coumarin
Gulyuz, Sevgi; Bayram, Duygu; Ozkose, Umut Ugur; Bolat, Zeynep Busra; Kocak, Polen; SAKA, ONGUN MEHMET; DEVRİM, BURCU; Khalily, Melek Parlak; TELCİ, DİLEK; ŞAHİN, FİKRETTİN; Özçubukçu, Salih; Sezer, Esma; TAŞDELEN, MEHMET ATİLLA; Alptürk, Onur; BOZKIR, ASUMAN; Yilmaz, Ozgur (Informa UK Limited, 2020-07-01)
Liposome surface modifications serve great potential applications of liposomes, for instance, increasing stability, bioactive liposome conjugates, and targeted drug, gene, and image agent delivery. In this study, novel tar...
Simple Tyrosine Derivatives Act as Low Molecular Weight Organogelators
Aykent, Guzide; Zeytun, Cansu; Marıon, Antoıne; Özçubukçu, Salih (Springer Science and Business Media LLC, 2019-03-20)
The gelation of L-Tyr(tBu)-OH in tetrahydrofuran (THF) was discovered serendipitously. It was noted that this tremendously low molecular weight (LMW) compound has the ability to gel a wide variety of organic solvents (e.g....
Structure-based design, synthesis and anticancer effect of cyclic Smac-polyarginine peptides
Khalily, Melek Parlak; GEREKÇİ, Selin; Gulec, Ezgi A.; Özen, Can; Özçubukçu, Salih (2018-11-01)
The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the i...
L-Tyr(tBu)-OH: An Outstanding Low Molecular Weight Organogelator
Aykent, Güzide; Zeytun, Cansu; Marion, Antoıne; Özçubukçu, Salih (2018-10-07)
In vivo bioluminescent imaging of cancer cells by using a bio-orthogonal ligation reaction
Almammadov, Toghrul; Özçubukçu, Salih; Bagci-Onder, Tugba; Kolemen, Safacan (2018-08-19)
Osteoconductive layer-by-layer films of Poly(4-hydroxy-L-proline ester) (PHPE) and Tannic acid
Onat, Bora; Özçubukçu, Salih; Banerjee, Sreeparna; Erel Göktepe, İrem (Elsevier BV, 2018-06-01)
Orthopedic implants have shown major success in clinics after successful orthopedic surgeries. However, they are also associated with several drawbacks such as local and systemic immune reaction in the body and improper in...
Synthesis of Chlorotoxin by Native Chemical Ligation
KARACA, Ulvi; Özçubukçu, Salih (2018-04-01)
Chlorotoxin (CLTX) is a neurotoxin found in the venom of the Israeli scorpion, Leirius quinquestriatus. It contains 36-amino acids with four disulfide bonds and inhibits low-conductance chloride channels. CLTX also binds t...
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