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Salih Özçubukçu

Department of Chemistry
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The synthesis of peptide-conjugated poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) (PEtOx-b-PLA) polymeric systems through the combination of controlled polymerization techniques and click reactions
Ozkose, Umut Ugur; Gulyuz, Sevgi; Parlak Khalily, Melek; Özçubukçu, Salih; BOZKIR, ASUMAN; TAŞDELEN, MEHMET ATİLLA; Alptürk, Onur; Yilmaz, Ozgur (2020-11-01)
To optimize the therapeutic effect of pharmaceutical agents, drug delivery systems tailored from FDA-approved polymers like poly(L-lactide) (PLA) is an effective strategy. Because of their hydrophobic character, these syst...
Synthesis, biocompatibility and gene encapsulation of poly(2-Ethyl 2-Oxazoline)-dioleoyl phosphatidylethanolamine (PEtOx-DOPE) and post-modifications with peptides and fluorescent dye coumarin
Gulyuz, Sevgi; Bayram, Duygu; Ozkose, Umut Ugur; Bolat, Zeynep Busra; Kocak, Polen; SAKA, ONGUN MEHMET; DEVRİM, BURCU; Khalily, Melek Parlak; TELCİ, DİLEK; ŞAHİN, FİKRETTİN; Özçubukçu, Salih; Sezer, Esma; TAŞDELEN, MEHMET ATİLLA; Alptürk, Onur; BOZKIR, ASUMAN; Yilmaz, Ozgur (Informa UK Limited, 2020-07-01)
Liposome surface modifications serve great potential applications of liposomes, for instance, increasing stability, bioactive liposome conjugates, and targeted drug, gene, and image agent delivery. In this study, novel tar...
Simple Tyrosine Derivatives Act as Low Molecular Weight Organogelators
Aykent, Guzide; Zeytun, Cansu; Marıon, Antoıne; Özçubukçu, Salih (Springer Science and Business Media LLC, 2019-03-20)
The gelation of L-Tyr(tBu)-OH in tetrahydrofuran (THF) was discovered serendipitously. It was noted that this tremendously low molecular weight (LMW) compound has the ability to gel a wide variety of organic solvents (e.g....
Structure-based design, synthesis and anticancer effect of cyclic Smac-polyarginine peptides
Khalily, Melek Parlak; GEREKÇİ, Selin; Gulec, Ezgi A.; Özen, Can; Özçubukçu, Salih (2018-11-01)
The second mitochondria-derived activator of caspase (Smac/DIABLO) is a pro-apoptotic protein that released from mitochondria into the cytosol when cells undergo apoptosis. Smac promotes caspase activation by binding the i...
In vivo bioluminescent imaging of cancer cells by using a bio-orthogonal ligation reaction
Almammadov, Toghrul; Özçubukçu, Salih; Bagci-Onder, Tugba; Kolemen, Safacan (2018-08-19)
Osteoconductive layer-by-layer films of Poly(4-hydroxy-L-proline ester) (PHPE) and Tannic acid
Onat, Bora; Özçubukçu, Salih; Banerjee, Sreeparna; Erel Göktepe, İrem (Elsevier BV, 2018-06-01)
Orthopedic implants have shown major success in clinics after successful orthopedic surgeries. However, they are also associated with several drawbacks such as local and systemic immune reaction in the body and improper in...
Synthesis of Chlorotoxin by Native Chemical Ligation
KARACA, Ulvi; Özçubukçu, Salih (2018-04-01)
Chlorotoxin (CLTX) is a neurotoxin found in the venom of the Israeli scorpion, Leirius quinquestriatus. It contains 36-amino acids with four disulfide bonds and inhibits low-conductance chloride channels. CLTX also binds t...
Enzyme Catalyzed Trans-Benzoin Condensation
BİLİR, Gökçil; AYHAN SITKI, Demir; Özçubukçu, Salih (2018-04-01)
Benzaldehyde lyase (BAL) is an enzyme that is used in the C-C bond cleavage and formation which was isolated first from Pseudomonas fluorescens Biovar I. It requires thiamine diphosphate (ThDP) and Mg(II) ions as cofactors...
The design and synthesis of a photo-controlled, peptide-based potential drug carrier
Parlak Khalily, Melek; Özçubukçu, Salih (The Scientific and Technological Research Council of Turkey, 2018-01-01)
Our focus in this study is on the design and synthesis of a light-responsive peptide-based nanocarrier in order to develop effective and biocompatible drug delivery systems. The synthesized nanocarrier is basically compose...
Optimization of synthetic route to PNA-T-OH monomers
Peptide nucleic acids are synthetic molecules crafted to mimic natural nucleic acids, and thus, they are widely utilized in many chemical, and, biomedical applications. Although there exist many approaches to synthesize mo...