Salih Özçubukçu

E-mail
osalih@metu.edu.tr
Department
Department of Chemistry
Scopus Author ID
Web of Science Researcher ID
Rational Design of an Acceptor-Chromophore-Relay-Catalyst Tetrad Assembly for Water Oxidation
Chalil Oglou, Ramadan; Ulusoy Ghobadi, Turkan Gamze; Saylam, Aytul; Bese, Damla; Bese, Cagri; Yaglioglu, Gul; Özçubukçu, Salih; Ozbay, Ekmel; Karadas, Ferdi (2024-01-01)
We report the step-by-step synthesis of a precious metal-free acceptor-chromophore-relay-catalyst tetrad assembly that exhibits a turnover frequency (TOF) of 7.5 × 10−3 s−1 under neutral conditions. Transient absorption sp...
Fullerene-based mimics of enhanced acetylcholine detection for the diagnosis of Alzheimer's disease
Soylemez, Saniye; Dolgun, Volkan; Özçubukçu, Salih (2023-10-01)
The design of sensitive and cost-effective enzyme-free sensor systems for the effective electrooxidation of acetylcholine (ACh) plays a key role in following up on Alzheimer's disease. We report a fullerenzyme-based cataly...
Tetraphenyl-1,4-dioxin and Tetraphenyl-pyrane-4-one: Old Molecules, New Insights
Soydan, Medine; Okyar, Burcu; ZORLU, YUNUS; Marıon, Antoıne; Özçubukçu, Salih (2023-05-01)
Aggregation-induced emission (AIE) is a phenomenon wherecertainmolecules or materials become highly luminescent when they aggregateor come together in a condensed state, such as a solid or a solution.Moreover, new molecule...
A Novel PEtOx-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery
Gülyüz, Sevgi; SESSEVMEZ, Melike; Ukuser, Gokcen; Khalily, Melek Parlak; Tiryaki, Selen; Sipahioglu, Tarik; Birgül, Kaan; Ömeroğlu, İpek; Özçubukçu, Salih; Telci, Dilek; Küçükgüzel, Ş. Güniz; Durmuş, Mahmut; Cevher, Erdal; Yılmaz, Özgür (2023-01-01)
This study focuses on creating a specialized nanogel for targeted drug delivery in cancer treatment, specifically targeting prostate cancer. This nanogel (referred to as SGK 636/Peptide 563/PEtOx nanogel) is created using ...
Highly Potent Peptide Therapeutics To Prevent Protein Aggregation in Huntington’s Disease
Khan, Anooshay; Özçelik, Cemile Elif; Begli, Ozge; Oguz, Oguzhan; Kesici, Mehmet Seçkin; Kasırga, Talip Serkan; Özçubukçu, Salih; YÜCA YILMAZ, Esra; Seker, Urartu Ozgur Safak (2023-01-01)
Huntington’s disease (HD) is a neurodegenerative disorder resulting from a significant amplification of CAG repeats in exon 1 of the Huntingtin (Htt) gene. More than 36 CAG repeats result in the formation of a mutant Htt (...
Downstream signalling of the disease-associated mutations on GPR56/ADGRG1
CEVHEROĞLU, ORKUN; Demir, Nil; Kesici, Mehmet Seçkin; Özçubukçu, Salih; Son, Çağdaş Devrim (2023-01-01)
GPR56/ADGRG1 is an adhesion G protein-coupled receptor (GPCR) and mutations on this receptor cause cortical malformation due to the over-migration of neural progenitor cells on brain surface. At pial surface, GPR56 interac...
Nanoarchitectonics of Fullerene-Based Enzyme Mimics for Osteogenic Induction of Stem Cells.
Yeniterzi, Dilara; Demirsoy, Zeynep; Saylam, Aytül; Özçubukçu, Salih; Gülseren, Gülcihan (2022-06-25)
Fullerene-Based Mimics of Biocatalysts Show Remarkable Activity and Modularity.
Gülseren, Gülcihan; Saylam, Aytül; Marıon, Antoıne; Özçubukçu, Salih (2021-09-29)
The design of catalysts with greater control over catalytic activity and stability is a major challenge with substantial impact on fundamental chemistry and industrial applications. Due to their unparalleled diversity, sel...
Poly(2-ethyl-2-oxazoline-co-ethyleneimine)-block-poly(epsilon-caprolactone) based micelles: synthesis, characterization, peptide conjugation and cytotoxic activity
Gulyuz, Sevgi; Ozkose, Umut Ugur; Khalily, Melek Parlak; Kesici, Mehmet Seçkin; Kocak, Polen; Bolat, Zeynep Busra; Kara, Aslı; Öztürk, Naile; Özçubukçu, Salih; Bozkır, Asuman; Alptürk, Onur; Telci, Dilek; Şahin, Fikrettin; Vural, Imran; Yilmaz, Ozgur (2021-07-01)
Here we present self-assembled polymeric micelles as potential delivery systems for therapeutic agents with highly tunable properties. The major goal of this study is to design breast and prostate cancer specific targeting...
A robust optimization approach for the breast cancer targeted design of PEtOx-b-PLA polymersomes
Oz, Umut Can; Bolat, Zeynep Busra; Ozkose, Umut Ugur; Gulyuz, Sevgi; Kucukturkmen, Berrin; Khalily, Melek Parlak; Özçubukçu, Salih; Yilmaz, Ozgur; Telci, Dilek; ESENDAĞLI, GÜNEŞ; Sahin, Fikrettin; Bozkir, Asuman (2021-04-01)
© 2021 Elsevier B.V.The equipping of nanoparticles with the peptide moiety recognizing a particular receptor, enables cell or tissue-specific targeting, therefore the optimization of the targeted nanoparticles is a key fac...
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