Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cells

Date

2007-12-01

Author

BARAN, YUSUF
Ural, Ali Ugur
Gündüz, Ufuk

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A major advancement in the treatment of chronic myeloid leukemia (CML) has been the development of imatinib, which has shown striking activity in the chronic phase and the accelerated phase, but less so in the blast phase of the disease. Despite high rates of hematologic and cytogenetic responses to therapy, the emergence of resistance to imatinib has been recognized as a major problem in the treatment of patients with CML.

Subject Keywords

Meg-01 cell line, Chronic myeloid leukemia, Imatinib mesylate, BCR/ABL, Multidrug resistance

URI

https://hdl.handle.net/11511/30931

Journal

HEMATOLOGY

DOI

https://doi.org/10.1080/10245330701384179

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

Y. BARAN, A. U. Ural, and U. Gündüz, “Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cells,” HEMATOLOGY, pp. 497–503, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30931.