Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population

2015-12-01
Mutlu, Pelin
Yalcin, Serap
Yaylaci, Atilay
Unsoy, Gozde
Saylam, Guleser
Akm, Istemihan
Gündüz, Ufuk
Show full item record
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
57
views
0
downloads
DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cancer susceptibility. The aim of this study was to investigate the association of XRCC3 Thr241Met single nucleotide polymorphism (SNP), smoking and alcohol consumption with the risk of laryngeal cancer in Turkish population. The frequencies of Thr241Met SNP were studied in 58 laryngeal cancer cases (SSC) and 67 healthy individuals. Genomic DNA was isolated from peripheral blood samples of both controls and laryngeal cancer cases. Thr241Met SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The genotype and allele frequencies of Thr241Met polymorphism were not statistically significant between the laryngeal cancer and control groups. Carrying mutant allele was not associated with the risk of laryngeal cancer. On the other hand, smoking and chronic alcohol consumption were associated with the risk of laryngeal cancer but there is no association between Thr241Met, smoking and alcohol consumption in laryngeal cancer cases. These results indicate that Thr241Met polymorphism was not associated with the development of laryngeal cancer in Turkish population. However, it should be kept in mind that the association of a polymorphism with cancer susceptibility can differ due to several factors such as cancer type, selection criteria, ethnic differences and size of the studied population.
DNA repair, XRCC3, SNP, Laryngeal cancer
https://hdl.handle.net/11511/31087
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
Graduate School of Natural and Applied Sciences, Article

Suggestions

Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met Polymorphisms in a Turkish Population and Their Association with the Risk of Chronic Lymphocytic Leukemia
Mutlu, Pelin; Yildirim, Murat; Nevruz, Oral; Cetin, Ahmet Turker; Avcu, Ferit (2015-09-01)
DNA repair systems are essential for cellular functions. Defects due to sequence variations in DNA repair genes can lead severe failure of cell functions and causing many cancer types including leukemia. The aim of this study was to investigate the relationship between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and susceptibility to chronic lymphocytic leukemia (CLL) in Turkish patients. In addition, genotype distribution of these polymorphisms was compared with other populations. The frequencies of ...
Detection of XRCC1 gene polymorphisms in Turkish head and neck squamous cell carcinoma patients: a comparative analysis with different populations
Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Yaylaci, Atilay; Saylam, Guleser; Akin, Istemihan; Korkmaz, Hakan; Gündüz, Ufuk (2015-03-01)
Purpose: X-ray repair cross-complementing (XRCC1) is one of the most important genes for the maintenance of genomic integrity and protection of cells from DNA damage. Although tobacco and alcohol consumption are the major risk factors for the development of head and neck squamous cell carcinoma (HNSCC), sequence variation in XRCC1 gene may alter HNSCC susceptibility. Reports on the relationship between HNSCC and polymorphisms in XRCC1 gene have been inconsistent so far. The aim of this study was to investig...
Investigation of structural properties of methylated human promoter regions in terms of DNA helical rise
Yaldız, Burcu; Aydın Son, Yeşim; Department of Bioinformatics (2014)
The infamous double helix structure of DNA was assumed to be a rigid, uniformly observed structure throughout the genomic DNA. However, the differences in physical structure of DNA in terms of local helical parameters such as twist, tilt, roll, rise and angles between adjacent base pairs in B-DNA molecule have been shown in many studies. This observed flexibility satisfies the known physical and chemical properties of DNA while providing a better model to explain how DNA fulfills its biological functions. W...
Influence of micropatterned polymeric substrates on cancer cell behavior
Ermiş Şen, Menekşe; Hasırcı, Vasıf Nejat; Demirci, Utkan; Department of Biomedical Engineering (2016)
The aim of this study was to develop micropatterned surfaces on biodegradable polymers such as PLGA and PLLA and non-degradable polymer PMMA to study cellular responses including proliferation, cellular morphology, nucleus morphology and deformation, focal adhesions and related pathways, cell division and cycle, and epithelial to mesenchymal transition in cancer cells. An array of nine surfaces decorated with micron sized micropillars were produced using photolithography. Saos-2 osteosarcoma and hOB human o...
IDENTIFYING ISOFORM SWITCHES IN BREAST CANCER
HENDEN, Şevki Onur; Can, Tolga; Department of Computer Engineering (2021-9-9)
Characterizing the human genome's molecular functions and their variations across people is vital for understanding the cellular processes behind human genetic characteristics and diseases. With the advent of single-cell RNA sequencing (scRNA-seq), it is now possible to investigate gene expression in individual cells. Although a number of scRNA-seq bioinformatics tools are now available, many of them focus on overall gene expression levels and, as a result, often ignore heterogeneity caused by individual tr...
Citation Formats
P. Mutlu et al., “Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population,” EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, pp. 3779–3784, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31087.
METU IIS - Integrated Information Service open@metu.edu.tr