Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population
Date
2015-12-01
Author
Mutlu, Pelin
Yalcin, Serap
Yaylaci, Atilay
Unsoy, Gozde
Saylam, Guleser
Akm, Istemihan
Gündüz, Ufuk
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
130
views
0
downloads
Cite This
DNA repair systems are essential for normal cell function. Genetic alterations in the DNA repair genes such as X-ray repair cross-complementing group 3 (XRCC3), can cause a change in protein activity which results in cancer susceptibility. The aim of this study was to investigate the association of XRCC3 Thr241Met single nucleotide polymorphism (SNP), smoking and alcohol consumption with the risk of laryngeal cancer in Turkish population. The frequencies of Thr241Met SNP were studied in 58 laryngeal cancer cases (SSC) and 67 healthy individuals. Genomic DNA was isolated from peripheral blood samples of both controls and laryngeal cancer cases. Thr241Met SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The genotype and allele frequencies of Thr241Met polymorphism were not statistically significant between the laryngeal cancer and control groups. Carrying mutant allele was not associated with the risk of laryngeal cancer. On the other hand, smoking and chronic alcohol consumption were associated with the risk of laryngeal cancer but there is no association between Thr241Met, smoking and alcohol consumption in laryngeal cancer cases. These results indicate that Thr241Met polymorphism was not associated with the development of laryngeal cancer in Turkish population. However, it should be kept in mind that the association of a polymorphism with cancer susceptibility can differ due to several factors such as cancer type, selection criteria, ethnic differences and size of the studied population.
Subject Keywords
DNA repair
,
XRCC3
,
SNP
,
Laryngeal cancer
URI
https://hdl.handle.net/11511/31087
Journal
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
DOI
https://doi.org/10.1007/s00405-014-3435-2
Collections
Graduate School of Natural and Applied Sciences, Article
Suggestions
OpenMETU
Core
Identification of XRCC1 Arg399Gln and XRCC3 Thr241Met Polymorphisms in a Turkish Population and Their Association with the Risk of Chronic Lymphocytic Leukemia
Mutlu, Pelin; Yildirim, Murat; Nevruz, Oral; Cetin, Ahmet Turker; Avcu, Ferit (2015-09-01)
DNA repair systems are essential for cellular functions. Defects due to sequence variations in DNA repair genes can lead severe failure of cell functions and causing many cancer types including leukemia. The aim of this study was to investigate the relationship between XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms and susceptibility to chronic lymphocytic leukemia (CLL) in Turkish patients. In addition, genotype distribution of these polymorphisms was compared with other populations. The frequencies of ...
Detection of XRCC1 gene polymorphisms in Turkish head and neck squamous cell carcinoma patients: a comparative analysis with different populations
Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Yaylaci, Atilay; Saylam, Guleser; Akin, Istemihan; Korkmaz, Hakan; Gündüz, Ufuk (2015-03-01)
Purpose: X-ray repair cross-complementing (XRCC1) is one of the most important genes for the maintenance of genomic integrity and protection of cells from DNA damage. Although tobacco and alcohol consumption are the major risk factors for the development of head and neck squamous cell carcinoma (HNSCC), sequence variation in XRCC1 gene may alter HNSCC susceptibility. Reports on the relationship between HNSCC and polymorphisms in XRCC1 gene have been inconsistent so far. The aim of this study was to investig...
IDENTIFYING ISOFORM SWITCHES IN BREAST CANCER
HENDEN, Şevki Onur; Can, Tolga; Department of Computer Engineering (2021-9-9)
Characterizing the human genome's molecular functions and their variations across people is vital for understanding the cellular processes behind human genetic characteristics and diseases. With the advent of single-cell RNA sequencing (scRNA-seq), it is now possible to investigate gene expression in individual cells. Although a number of scRNA-seq bioinformatics tools are now available, many of them focus on overall gene expression levels and, as a result, often ignore heterogeneity caused by individual tr...
Assessment of changes in the dielectric properties of multidrug resistant cancer cells by electrorotation technique /
Bahrieh, Garsha; Külah, Haluk; Department of Electrical and Electronics Engineering (2014)
With recent advances in microfabrication technologies different methodologies are employed to study the dielectric properties of the biological systems. These include electrorotation (ER), dielectrophoresis, microelectrical impedance spectroscopy, and impedance flow cytometry. Among them, ER is utilized as a high accuracy approach in determining the membrane and interior dielectric properties of single cells. In addition, in cancer therapy, cancer cells are developing resistance toward the chemotherapeutic ...
Isolation of High-Quality RNA from Pichia pastoris
Öztürk, Sibel; Demir, İrem; Çalık, Pınar (Wiley, 2019-12-01)
Analysis of RNA structuromes provides new insights into cellular processes, enabling systems biology and biotechnology researchers to calculate promoter and terminator strengths and to directly observe how differing circuit states impact host gene expression and the burdens imposed by the circuits. Such analysis, however, is crucially dependent on the availability of highly pure, intact RNA isolated from fresh or frozen cell cultures. RNA extraction from the yeast Pichia pastoris requires specific pretreatm...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
P. Mutlu et al., “Association between XRCC3 Thr241Met polymorphism and laryngeal cancer susceptibility in Turkish population,”
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
, pp. 3779–3784, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31087.