Understanding the cell behavior on nano-/micro-patterned surfaces

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Date

2012-09-01

Author

Hasırcı, Vasıf Nejat

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Aim: This article reports on studies conducted in the same laboratory on interactions between patterned substrates with different pattern dimensions and chemistries, and various types of cells. Materials & methods: In order to compare the influence of various parameters, bone marrow stromal cells, retinal pigment epithelial cells, human corneal stromal cells (keratocytes), Saos-2 (human osteosarcoma cells), human microvascular endothelial cells and vascular smooth muscle cells were tested on surfaces with different physical patterns and chemical properties. Results: It was observed that cell type and surface topography are more influential than surface chemistry in determining the alignment tendency of a cell on a substrate surface. Low walls (several microns high) could not confine cells into the microgrooves of the films but alignment was still possible if the cells had a natural alignment property. Conclusion: This information is very useful in designing tissue engineering scaffolds and in the long-term success of implants.

Subject Keywords

Micropatterning, Nanopatterning, Surface modification, Tissue engineering

URI

https://hdl.handle.net/11511/31182

Journal

NANOMEDICINE

DOI

https://doi.org/10.2217/nnm.12.7

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

V. N. Hasırcı, “Understanding the cell behavior on nano-/micro-patterned surfaces,” NANOMEDICINE, pp. 1375–1389, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31182.