Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer

2014-07-01
Gündüz, Ufuk
Tansik, Gulistan
Mutlu, Pelin
Unsoy, Gozde
YAKAR, ARZU
Khodadust, Rouhollah
Gunduz, Gungor
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Conventional cancer chemotherapies cannot differentiate between healthy and cancer cells, and lead to severe side effects and systemic toxicity. Another major problem is the drug resistance development before or during the treatment. In the last decades, different kinds of controlled drug delivery systems have been developed to overcome these shortcomings. The studies aim targeted drug delivery to tumor site. Magnetic nanoparticles (MNP) are potentially important in cancer treatment since they can be targeted to tumor site by an externally applied magnetic field. In this study, MNPs were synthesized, covered with biocompatible polyethylene glycol (PEG) and conjugated with folic acid. Then, anti-cancer drug idarubicin was loaded onto the nanoparticles. Shape, size, crystal and chemical structures, and magnetic properties of synthesized nanoparticles were characterized. The characterization of synthesized nanoparticles was performed by dynamic light scattering (DLS), Fourier transforminfrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscopy (SEM) analyses. Internalization and accumulation of MNPs in MCF-7 cells were illustrated by light and confocal microscopy. Empty MNPs did not have any toxicity in the concentration ranges of 0-500 mu g/mL on MCF-7 cells, while drug-loaded nanoparticles led to significant toxicity in a concentration-dependent manner. Besides, idarubicin-loaded MNPs exhibited higher toxicity compared to free idarubicin. The results are promising for improvement in cancer chemotherapy. (C) 2014 Elsevier Masson SAS. All rights reserved.
Idarubicin, Folic Acid, Polyethylene Glycol (PEG), Magnetic Nanoparticle, Drug Delivery, MCF-7
https://hdl.handle.net/11511/31423
BIOMEDICINE & PHARMACOTHERAPY
Graduate School of Natural and Applied Sciences, Article

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Citation Formats
U. Gündüz et al., “Idarubicin-loaded folic acid conjugated magnetic nanoparticles as a targetable drug delivery system for breast cancer,” BIOMEDICINE & PHARMACOTHERAPY, pp. 729–736, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31423.
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