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Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.
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Date
2014-12-01
Author
Turan, IS
Cakmak, FP
Kahraman, Deniz Cansen
Atalay, Rengül
Akkaya, EU
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Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.
Subject Keywords
BODIPY dyes
,
Photochemistry
,
Photodynamic action
,
Photosensitizers
,
Singlet oxygen
URI
https://hdl.handle.net/11511/31575
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
DOI
https://doi.org/10.1002/chem.201405450
Collections
Graduate School of Informatics, Article
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I. Turan, F. Cakmak, D. C. Kahraman, R. Atalay, and E. Akkaya, “Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.,”
Chemistry (Weinheim an der Bergstrasse, Germany)
, pp. 16088–92, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31575.