Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.

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Date

2014-12-01

Author

Turan, IS
Cakmak, FP
Kahraman, Deniz Cansen
Atalay, Rengül
Akkaya, EU

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Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high intracellular glutathione concentrations within cancer cells, a series of BODIPY-based sensitizers that can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module were designed and synthesized. Cell culture studies not only validate our design, but also suggest an additional role for the relatively hydrophobic quencher module in the internalization of the photosensitizer.

Subject Keywords

BODIPY dyes, Photochemistry, Photodynamic action, Photosensitizers, Singlet oxygen

URI

https://hdl.handle.net/11511/31575

Journal

Chemistry (Weinheim an der Bergstrasse, Germany)

DOI

https://doi.org/10.1002/chem.201405450

Collections

Graduate School of Informatics, Article

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Citation Formats

I. Turan, F. Cakmak, D. C. Kahraman, R. Atalay, and E. Akkaya, “Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action.,” Chemistry (Weinheim an der Bergstrasse, Germany), pp. 16088–92, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31575.