Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study

Bakirdere, Sezgin
Arslan, Yasin
Ataman, Osman Yavuz
We investigated the possible relationship between boron exposure and prostate cancer (PCa) for men living and being employed at boron mines in villages with rich boron minerals. Out of 456 men studied, 159 were from villages with rich boron sources and boron levels in drinking water of > 1 mg L(-1) and these men formed the study group, while 63 from villages with rich boron sources and boron levels in drinking water of < 1 mg L(-1) were enrolled into control group 1. A further 234 subjects from other villages with no boron mines were considered as control group 2. Prostate specific antigen (PSA) levels could be obtained from a total of 423 men. Urinary boron concentration as an indicator of boron exposure in 63 subjects, prostatic volumes by transrectal ultrasonography in 39 subjects, and prostatic biopsies in 36 subjects were obtained for study and control groups. The daily boron exposure was calculated according to urinary boron levels. Although there was no significant difference among the groups in terms of total PSA levels, the number of subjects with tPSA a parts per thousand yen2.5 and tPSA a parts per thousand yen10.0 ng dL(-1) prostatic volumes in men whose prostates were biopsied (p < 0.012) was significantly lower in the study group as compared with those in the control group 2. These results suggested that high exposure to boron might have an implication within the prostatic cellular processes related to hyperplasia and carcinogenesis, even though we did not find a statistically significant association between PCa and boron exposure.


Effects of Chronic Boron Exposure on Semen Profile
KORKMAZ, MEHMET; Yenigun, Mehmet; Bakirdere, Sezgin; Ataman, Osman Yavuz; Keskin, Sıddık; MÜEZZİNOĞLU, TALHA; LEKİLİ, MURAT (2011-11-01)
The possible changes in semen quality were studied in men living in a boron mining area. The subjects in the boron group had exposure to boron at an average level of 6.5 mg/day, as determined by urinary analysis. The results obtained by the boron group were compared to those obtained for the control group whose subjects were living in the same geographical area but away from the boron region; average exposure level was 1.4 mg/day for this group. The semen samples were analyzed according to the recommendatio...
Effectiveness of anaerobic biomass in adsorbing heavy metals
Haytoglu, B; Demirer, Göksel Niyazi; Yetiş, Ülkü (2001-01-01)
This study focuses on the effectiveness of waste anaerobic dead biomass (AIDE) in adsorbing heavy metals, namely Pb(II), Cr(VI), Cu(II), Ni(II) and Zn(II). The metal uptake capacity of ADB was investigated and compared with the values for various biomass types from the literature. The biomass, which was grown under laboratory conditions using a synthetic wastewater, was used throughout the study after sterilization. The maximum metal adsorptive capacities were evaluated by running isotherm tests at 25 degre...
A Study on development of machinable calcium phosphate based bio-composites with zirconia, boron oxide and lanthanum oxide
Khoshsima, Sina; Evis, Zafer; Özgül, Metin; Department of Biomedical Engineering (2015)
The aim of this study was to investigate the microstructure, mechanical and biological properties of pure hydroxyapatite and composites of hydroxyapatite with zirconia, boron oxide and lanthanum oxide. Hydroxyapatite was synthesized via precipitation method and sintered at 1100°C for 1 h. It was observed that relative density of the sintered composites including zirconia was increased while the density of composites including boron oxide decreased. For physical and structural analysis, X-ray diffraction, sc...
Expression of the genes encoding important transport system proteins in silver resistant escherichia coli mutants
Uyanık, Gökçe; Gözen, Ayşe Gül; Department of Biotechnology (2019)
Heavy metals, such as silver (Ag), copper (Cu) or mercury (Hg), have been used as antimicrobial agents for quite some time in human history. Silver has inhibitory or lethal effects on a broad range of bacteria and fungi. Furthermore, heavy metals are useful against viruses. The applications of silver dealing with bacteria comprise industrial, agricultural, medical and healthcare areas. They were used as disinfectants in hospitals as well as in the treatment of several infectious diseases such as tuberculosi...
Aydemir, Umut; Erel Göktepe, İrem; Akdağ, Akın; Department of Biochemistry (2021-9-24)
Boron Neutron Capture Therapy (BNCT) is a non-invasive radiotherapy technique which is based on delivery of non-radioactive 10B compounds to cancer cells and irradiation of the tumour tissues with low energy thermal neutrons. It is a promising radiotherapy technique due to reduce the side effects of the treatment. The main goal of this thesis is to prepare a non-toxic polymer vehicle to provide efficient delivery of 10B to cancer cells. Dodecahydro-closo-dodecaborate (B12H12)2- (B12) anion was utilized as a...
Citation Formats
T. MÜEZZİNOĞLU et al., “Prevalence of Prostate Cancer in High Boron-Exposed Population: A Community-Based Study,” BIOLOGICAL TRACE ELEMENT RESEARCH, pp. 49–57, 2011, Accessed: 00, 2020. [Online]. Available: