Iron metabolism and drug resistance in cancer

Kazan, Hasan Huseyin
Urfali-Mamatoglu, Cagri
Gündüz, Ufuk
Iron is an essential inorganic element for various cellular events. It is directly associated with cell proliferation and growth; therefore, it is expected that iron metabolism is altered in tumor cells which usually have rapid growth rates. The studies on iron metabolism of tumor cells have shown that tumor cells necessitated higher concentrations of iron and the genes of iron uptake proteins were highly over-expressed. However, there are limited number of studies on overall iron metabolism in drug-resistant tumor cells. In this article, we evaluated the studies reporting the relationship between drug resistance and iron metabolism and the utilization of this knowledge for the reversal of drug resistance. Also, the studies on iron-related cell death mechanism, ferroptosis, and its relation to drug resistance were reviewed. We focus on the importance of iron metabolism in drug-resistant cancer cells and how alterations in iron metabolism participate in drug-resistant phenotype.


Chemoenzymatic functionalization of cyclic 1,3-diketones
Fındık, Hamide; Demir, Ayhan Sıtkı; Department of Chemistry (2004)
Chiral a-hydroxy and a-acetoxy enones are important starting materials in the synthesis of many biologically active materials. In this work, enantiomerically pure ?-hydroxy enone and polyoxo cyclohexenones are synthesized starting from 1,3-cyclohexandione. In the first step, 1,3-cyclohexandione is protected under acid catalyzation and 3-methoxy-2-methyl-2-cyclohexen-1-one is obtained. a'-Acetoxy enone is obtained by Mn(OAc)3 mediated oxidation which is an attractive alternative to other multi-step procedure...
ERGUCYENER, C; AYGUN, S; Ataman, Osman Yavuz; TEMIZER, A (1988-01-01)
Mercury speciation in aqueous solutions containing inorganic mercury and methylmercury has been demonstrated using electrochemical separation prior to determination by cold-vapour atomic absorption spectrometry. Approximately 95% of the inorganic mercury was electro-deposited on a Pt electrode at –0.1 V, whereas for methylmercury –0.2 V or even more negative potentials were required. Organic mercury was determined by NaBH4 reduction after electrochemical separation. Inorganic mercury was determined in the o...
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line
Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gündüz, Ufuk (2014-11-01)
In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by Fourier transform infrared spectroscopy, x-ray diffraction, dynamic light scattering, thermal gravimetric analysis, vibrating sample magnetometry, and transmission electron microscopy analyses. Doxorubicin was loaded onto PHB-MNPs, and the release efficiencies at different pHs were studied un...
Reactive iron in the seafloor of Cilician basin, Eastern Mediterranean
Ermiş, Esra; Örek, Hasan; Tezcan, Devrim; Yücel, Mustafa (null; 2017-08-18)
Reactive iron is a relatively more biogeochemically active part of solid phase iron pool in marine sediments. They can transport organic carbon, take part in microbial respiratory pathways and play a major role in controlling phosphate retention or release. The latterfunction is especially crucial in the oligotrophic Eastern Mediterranean(EM), where phosphate adsorption onto dust and river-derived reactive iron minerals might have yielded in oligotrophy. Here we describefor the...
Measurement of the intrinsic radiopurity of (CS)-C-137/U-235/U-238/Th-232 in CsI(Tl) crystal scintillators
Zhu, YF; Lin, ST; Singh, V; Chang, WC; Deniz, M; Lai, WP; Li, HB; Li, J; Li, Y; Liao, HY; Lee, FS; Wong, HT; Wu, SC; Yue, Q; Zhou, ZY (Elsevier BV, 2006-02-15)
The inorganic crystal scintillator CsI(TI) has been used for low energy neutrino and Dark Matter experiments, where the intrinsic radiopurity is an issue of major importance. Low-background data were taken with a Csl(TI) crystal array at the Kuo-Sheng Reactor Neutrino Laboratory. The pulse shape discrimination capabilities of the crystal, as well as the temporal and spatial correlations of the events, provide powerful means of measuring the intrinsic radiopurity of Cs-137 as well as the U-215, U-238 and Th-...
Citation Formats
H. H. Kazan, C. Urfali-Mamatoglu, and U. Gündüz, “Iron metabolism and drug resistance in cancer,” BIOMETALS, pp. 629–641, 2017, Accessed: 00, 2020. [Online]. Available: