Iron metabolism and drug resistance in cancer

Kazan, Hasan Huseyin
Urfali-Mamatoglu, Cagri
Gündüz, Ufuk
Iron is an essential inorganic element for various cellular events. It is directly associated with cell proliferation and growth; therefore, it is expected that iron metabolism is altered in tumor cells which usually have rapid growth rates. The studies on iron metabolism of tumor cells have shown that tumor cells necessitated higher concentrations of iron and the genes of iron uptake proteins were highly over-expressed. However, there are limited number of studies on overall iron metabolism in drug-resistant tumor cells. In this article, we evaluated the studies reporting the relationship between drug resistance and iron metabolism and the utilization of this knowledge for the reversal of drug resistance. Also, the studies on iron-related cell death mechanism, ferroptosis, and its relation to drug resistance were reviewed. We focus on the importance of iron metabolism in drug-resistant cancer cells and how alterations in iron metabolism participate in drug-resistant phenotype.


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Iron is one of the key elements in the ocean which has wide interconnections with other essential elements (i.e., C, N, P, O, Mn, S) and fundamental mechanisms (i.e., photosynthesis, respiration, chemosynthesis). The critical role of iron, since the beginning of life until the modern oceans, was increasing with biogeochemical evolution creating new niches for iron. Despite iron is ubiquitous on land, its trace level presence in the ocean creates difficulties for iron studies. Hence, the complex cycle of iro...
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Fındık, Hamide; Demir, Ayhan Sıtkı; Department of Chemistry (2004)
Chiral a-hydroxy and a-acetoxy enones are important starting materials in the synthesis of many biologically active materials. In this work, enantiomerically pure ?-hydroxy enone and polyoxo cyclohexenones are synthesized starting from 1,3-cyclohexandione. In the first step, 1,3-cyclohexandione is protected under acid catalyzation and 3-methoxy-2-methyl-2-cyclohexen-1-one is obtained. a'-Acetoxy enone is obtained by Mn(OAc)3 mediated oxidation which is an attractive alternative to other multi-step procedure...
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line
Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gündüz, Ufuk (2014-11-01)
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Reactive iron in the seafloor of Cilician basin, Eastern Mediterranean
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Reactive iron is a relatively more biogeochemically active part of solid phase iron pool in marine sediments. They can transport organic carbon, take part in microbial respiratory pathways and play a major role in controlling phosphate retention or release. The latterfunction is especially crucial in the oligotrophic Eastern Mediterranean(EM), where phosphate adsorption onto dust and river-derived reactive iron minerals might have yielded in oligotrophy. Here we describefor the...
Citation Formats
H. H. Kazan, C. Urfali-Mamatoglu, and U. Gündüz, “Iron metabolism and drug resistance in cancer,” BIOMETALS, pp. 629–641, 2017, Accessed: 00, 2020. [Online]. Available: