Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Iron metabolism and drug resistance in cancer
Date
2017-10-01
Author
Kazan, Hasan Huseyin
Urfali-Mamatoglu, Cagri
Gündüz, Ufuk
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
171
views
0
downloads
Cite This
Iron is an essential inorganic element for various cellular events. It is directly associated with cell proliferation and growth; therefore, it is expected that iron metabolism is altered in tumor cells which usually have rapid growth rates. The studies on iron metabolism of tumor cells have shown that tumor cells necessitated higher concentrations of iron and the genes of iron uptake proteins were highly over-expressed. However, there are limited number of studies on overall iron metabolism in drug-resistant tumor cells. In this article, we evaluated the studies reporting the relationship between drug resistance and iron metabolism and the utilization of this knowledge for the reversal of drug resistance. Also, the studies on iron-related cell death mechanism, ferroptosis, and its relation to drug resistance were reviewed. We focus on the importance of iron metabolism in drug-resistant cancer cells and how alterations in iron metabolism participate in drug-resistant phenotype.
Subject Keywords
Iron metabolism
,
Chemotherapy
,
Drug resistance
,
Ferroptosis
URI
https://hdl.handle.net/11511/31846
Journal
BIOMETALS
DOI
https://doi.org/10.1007/s10534-017-0037-7
Collections
Graduate School of Natural and Applied Sciences, Article
Suggestions
OpenMETU
Core
Seafloor Iron Mobilization Across The Deep-Water Redox Gradients Of The Black Sea And The Sea Of Marmara
Alımlı, Nimet; Yücel, Mustafa; Department of Chemical Oceanography (2022-8)
Iron is one of the key elements in the ocean which has wide interconnections with other essential elements (i.e., C, N, P, O, Mn, S) and fundamental mechanisms (i.e., photosynthesis, respiration, chemosynthesis). The critical role of iron, since the beginning of life until the modern oceans, was increasing with biogeochemical evolution creating new niches for iron. Despite iron is ubiquitous on land, its trace level presence in the ocean creates difficulties for iron studies. Hence, the complex cycle of iro...
MERCURY SPECIATION BY ELECTROCHEMICAL SEPARATION AND COLD-VAPOR ATOMIC-ABSORPTION SPECTROMETRY
ERGUCYENER, C; AYGUN, S; Ataman, Osman Yavuz; TEMIZER, A (1988-01-01)
Mercury speciation in aqueous solutions containing inorganic mercury and methylmercury has been demonstrated using electrochemical separation prior to determination by cold-vapour atomic absorption spectrometry. Approximately 95% of the inorganic mercury was electro-deposited on a Pt electrode at –0.1 V, whereas for methylmercury –0.2 V or even more negative potentials were required. Organic mercury was determined by NaBH4 reduction after electrochemical separation. Inorganic mercury was determined in the o...
Chemoenzymatic functionalization of cyclic 1,3-diketones
Fındık, Hamide; Demir, Ayhan Sıtkı; Department of Chemistry (2004)
Chiral a-hydroxy and a-acetoxy enones are important starting materials in the synthesis of many biologically active materials. In this work, enantiomerically pure ?-hydroxy enone and polyoxo cyclohexenones are synthesized starting from 1,3-cyclohexandione. In the first step, 1,3-cyclohexandione is protected under acid catalyzation and 3-methoxy-2-methyl-2-cyclohexen-1-one is obtained. a'-Acetoxy enone is obtained by Mn(OAc)3 mediated oxidation which is an attractive alternative to other multi-step procedure...
Polyhydroxybutyrate-Coated Magnetic Nanoparticles for Doxorubicin Delivery: Cytotoxic Effect Against Doxorubicin-Resistant Breast Cancer Cell Line
Yalcin, Serap; Unsoy, Gozde; Mutlu, Pelin; Khodadust, Rouhollah; Gündüz, Ufuk (2014-11-01)
In this study, polyhydroxybutyrate (PHB)-coated magnetic nanoparticles (MNPs) were prepared by coprecipitation of iron salts (Fe2+ and Fe3+) by ammonium hydroxide. Characterizations of PHB-coated MNPs were performed by Fourier transform infrared spectroscopy, x-ray diffraction, dynamic light scattering, thermal gravimetric analysis, vibrating sample magnetometry, and transmission electron microscopy analyses. Doxorubicin was loaded onto PHB-MNPs, and the release efficiencies at different pHs were studied un...
Reactive iron in the seafloor of Cilician basin, Eastern Mediterranean
Ermiş, Esra; Örek, Hasan; Tezcan, Devrim; Yücel, Mustafa (null; 2017-08-18)
Reactive iron is a relatively more biogeochemically active part of solid phase iron pool in marine sediments. They can transport organic carbon, take part in microbial respiratory pathways and play a major role in controlling phosphate retention or release. The latterfunction is especially crucial in the oligotrophic Eastern Mediterranean(EM), where phosphate adsorption onto dust and river-derived reactive iron minerals might have yielded in oligotrophy. Here we describefor the...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
H. H. Kazan, C. Urfali-Mamatoglu, and U. Gündüz, “Iron metabolism and drug resistance in cancer,”
BIOMETALS
, pp. 629–641, 2017, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31846.