A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering

Date

2020-04-01

Author

Alissa Alam, Hani
Dalgıç, Ali Deniz
Tezcaner, Ayşen
Özen, Can
Keskin, Dilek

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Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in terms of morphology, chemistry, mechanical property, water retention, weight loss, porosity and release properties. Coaxial fibers supported duel release of model hydrophilic protein (Beta-lactoglobulin) and hydrophobic agent vitamin K2. Novel PCL/P-188(Shell):Gelatin/P-188(Core) coaxial scaffold had superior stability, average weight loss, no swelling behavior, controlled release of Beta-lactoglobulin and vitamin K2, enhanced Saos-2 cell viability and ALP activity and could be a good candidate as a bone tissue scaffold.

Subject Keywords

Wet coaxial electrospinning, Poloxamer 188, Dual release, Bone scaffold, Beta-lactoglobulin, Vitamin K2

URI

https://hdl.handle.net/11511/32165

Journal

International Journal of Polymeric Materials and Polymeric Biomaterials

DOI

https://doi.org/10.1080/00914037.2019.1581198

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

H. Alissa Alam, A. D. Dalgıç, A. Tezcaner, C. Özen, and D. Keskin, “A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering,” International Journal of Polymeric Materials and Polymeric Biomaterials, pp. 339–350, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32165.