In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems

Sendil-Keskin, D
Altunay, H
Wise, DL
Hasırcı, Vasıf Nejat
Pain is the most common and feared symptom for patients, especially those with cancer. Treatment of chronic pain with conventional ways of medication usually fails with increasing severity of the pain. New approaches enabling the prolonged provision of pain relievers are required. We designed a controlled release system of pain relievers, mainly for opioids (morphine, M, codeine, C, and hydromorphone, HM), and a local anesthetic (bupivacaine, BP) in the form Of poly(L-lactide-colycolide) (PLGA) rods. The efficacy of these rods implanted alone or in combination in relieving chronic pain in rats caused by the ligation of the sciatic nerve of their right hind limbs was studied. The two most common tests for measuring analgesia, i.e. tail-flick tests, that show analgesia at sites other than the site of injury, were used to study the degree of systemic distribution of the drugs and paw-withdrawal tests were used to study the analgesia at the site of injury.


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Control of chronic, severe pain is a difficult and important clinical problem for most patients, especially those with cancer, Although current applications are insufficient for a satisfactory solution to this problem, the rate of disease incidence is increasing worldwide, thus making the problem more apparent. Based on this fact, this study was designed with the ultimate goal of formulating a controlled release system of pain relievers, mainly opioids, for the local treatment of pain to achieve satisfactor...
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Citation Formats
D. Sendil-Keskin, H. Altunay, D. Wise, and V. N. Hasırcı, “In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems,” JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, pp. 497–514, 2003, Accessed: 00, 2020. [Online]. Available: