Assessment of biodegradable controlled release rod systems for pain relief applications

Sendil, D
Wise, DL
Hasırcı, Vasıf Nejat
Control of chronic, severe pain is a difficult and important clinical problem for most patients, especially those with cancer, Although current applications are insufficient for a satisfactory solution to this problem, the rate of disease incidence is increasing worldwide, thus making the problem more apparent. Based on this fact, this study was designed with the ultimate goal of formulating a controlled release system of pain relievers, mainly opioids, for the local treatment of pain to achieve satisfactory, fast, and less side effect-related relief and to provide a better life status for chronic pain patients. Two copolymers of a biodegradable polymer poly(L-lactide-co-glycolide) (PLGA) were used to prepare an implantable rod type drug release system containing either an analgesic or anesthetic type of pain reliever. In vitro drug release kinetics of these systems were studied. It was observed that release from PLGA 85: 15 was more zero-order than it was from PLGA 50: 50. A zero-order release rate was obtained for codeine, hydromorphone, and bupivacaine from PLGA (85: 15) rods. They, however, were released from PLGA (50: 50) rods with Higuchi kinetics. The drug solubility was also influential on release rate, as shown by the zero-order morphine release from PLGA (50:50) rods. Scanning electron micrographs (SEMs) of the monolithic rods revealed erosion of the rods and the removal of drug crystals from the rod structure.


In vivo pain relief effectiveness of an analgesic-anesthetic carrying biodegradable controlled release rod systems
Sendil-Keskin, D; Altunay, H; Wise, DL; Hasırcı, Vasıf Nejat (2003-01-01)
Pain is the most common and feared symptom for patients, especially those with cancer. Treatment of chronic pain with conventional ways of medication usually fails with increasing severity of the pain. New approaches enabling the prolonged provision of pain relievers are required. We designed a controlled release system of pain relievers, mainly for opioids (morphine, M, codeine, C, and hydromorphone, HM), and a local anesthetic (bupivacaine, BP) in the form Of poly(L-lactide-colycolide) (PLGA) rods. The ef...
Development and characterization of cortisone derivative drugcarrying polymeric microspheres
Öcal, Yiğit; Keskin, Dilek; Özen, Seza; Department of Biomedical Engineering (2011)
In this study, it is aimed to develop an injectable controlled release system of PCL and P(L,DL)LA microspheres loaded with TA and/or Ral for local treatment of rheumatoid arthritis which will avoid from systemic side effects of traditional administration and eliminate problems caused by direct local injections. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disorder that most commonly causes inflammation and tissue damage in joints and tendon sheaths. Current strategies for the disease are ma...
Tailoring magnetic PLGA nanoparticles suitable for doxorubicin delivery
Tansik, Gulistan; YAKAR, ARZU; Gündüz, Ufuk (2013-12-07)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells, which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale-based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an exter...
Characterization and Evaluation of Triamcinolone, Raloxifene, and Their Dual-Loaded Microspheres as Prospective Local Treatment System in Rheumatic Rat Joints
Ocal, Yigit; Kurum, Baris; Karahan, Siyami; Tezcaner, Ayşen; Ozen, Seza; Keskin, Dilek (Elsevier BV, 2014-8)
In this study, injectable microspheres were developed for the local treatment of joint degeneration in rheumatoid arthritis (RA). Microspheres loaded with triamcinolone (TA), a corticosteroid drug, and/or raloxifene (Ral), a cartilage regenerative drug, were prepared with a biodegradable and biocompatible polymer, polycaprolactone (PCL). Microspheres were optimized for particle size, structural properties, drug release, and loading properties. In vitro release of Ral was very slow because of the low solubil...
Investigaton of chemopreventive properties of Urtica Dioica L., in MCF-7 and MDA231 breast cancer cell lines
Güler, Elif; İşcan, Mesude; Department of Biology (2011)
Cancer is a major health problem in developing world with mostly unsufficient treatment. Cancer prevention through dietary modification appears to be a practical and cost effective possibility. The aim of present study is to investigate the chemical components of “Urtica diocia,L (U. diocia) grown in Turkey” and the possible protective potential of its aqueous extract against breast cancer cell lines. U. diocia was extracted by maceration method which was performed for 6,12, 24, and 36 hours, at 50°C, 37°C,...
Citation Formats
D. Sendil, D. Wise, and V. N. Hasırcı, “Assessment of biodegradable controlled release rod systems for pain relief applications,” JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, pp. 1–15, 2002, Accessed: 00, 2020. [Online]. Available: