Quantification of Type, Timing, and Extent of Cell Body and Nucleus Deformations Caused by the Dimensions and Hydrophilicity of Square Prism Micropillars

Date

2016-12-01

Author

Hasturk, Onur
Sivas, Abdullah
Karasözen, Bülent
Demirci, Utkan
Hasırcı, Nesrin
Hasırcı, Vasıf Nejat

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Novel digital analysis strategies are developed for the quantification of changes in the cytoskeletal and nuclear morphologies of mesenchymal stem cells cultured on micropillars. Severe deformations of nucleus and distinct conformational changes of cell body ranging from extensive elongation to branching are visualized and quantified. These deformations are caused mainly by the dimensions and hydrophilicity of the micropillars.

Subject Keywords

Conformational changes, Cytoskeleton, Micropillars, Nucleus deformations, Oxygen plasma modification

URI

https://hdl.handle.net/11511/32435

Journal

ADVANCED HEALTHCARE MATERIALS

DOI

https://doi.org/10.1002/adhm.201600857

Collections

Graduate School of Applied Mathematics, Article

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Citation Formats

O. Hasturk, A. Sivas, B. Karasözen, U. Demirci, N. Hasırcı, and V. N. Hasırcı, “Quantification of Type, Timing, and Extent of Cell Body and Nucleus Deformations Caused by the Dimensions and Hydrophilicity of Square Prism Micropillars,” ADVANCED HEALTHCARE MATERIALS, pp. 2972–2982, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32435.