Quantification of Type, Timing, and Extent of Cell Body and Nucleus Deformations Caused by the Dimensions and Hydrophilicity of Square Prism Micropillars

Date

2016-12-01

Author

Hasturk, Onur
Sivas, Abdullah
Karasözen, Bülent
Demirci, Utkan
Hasırcı, Nesrin
Hasırcı, Vasıf Nejat

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

131
views

0
downloads

Novel digital analysis strategies are developed for the quantification of changes in the cytoskeletal and nuclear morphologies of mesenchymal stem cells cultured on micropillars. Severe deformations of nucleus and distinct conformational changes of cell body ranging from extensive elongation to branching are visualized and quantified. These deformations are caused mainly by the dimensions and hydrophilicity of the micropillars.

Subject Keywords

Conformational changes, Cytoskeleton, Micropillars, Nucleus deformations, Oxygen plasma modification

URI

https://hdl.handle.net/11511/32435

Journal

ADVANCED HEALTHCARE MATERIALS

DOI

https://doi.org/10.1002/adhm.201600857

Collections

Graduate School of Applied Mathematics, Article

Suggestions

OpenMETU
Core

Novel annulation reactions for the synthesis of substituted pyrroles darzens reaction of acyl phosphonates with α-bromo ketones : selective synthesis of cis- and transepoxyphosphonates Emrullah, Mustafa; Demir, Ayhan Sıtkı; Department of Chemistry (2009) In the first part of this thesis, it is aimed to develope methods for the synthesis of trisubstituted pyrrrole derivatives. 2-Aminopyrrroles, alkoxy and sulfonyl substittitued pyrrole derivatives as well as pirolinones show interesting biological activities and are precursor of well know drugs. Although there is a number of methods for the synthesis of pyrroles, the synthesis of 2-aminopyrroles is limited to few works and is not widely known. Therefore, it is still an important goal in organic chemistry to ...
Assessment of effects of multi drug resistance on dielectric properties of K562 leukemic cells using electrorotation Bahrieh, Garsha; Erdem, Murat; Ozgur, Ebru; Gündüz, Ufuk; Külah, Haluk (2014-01-01) In this study, dielectric characterization of multidrug resistant (MDR) K562 human leukemia cells was carried out using a MEMS based electrorotation (ER) device with 3D electrodes. P-glycoprotein (P-gp) dependent MDR causes variation in cell dielectric properties (cell interior conductivity (sigma(i)), membrane capacitance (C-m) and total effective membrane conductance (G(m)*)) due to overexpression of P-gp, which modulates the activity of membrane-bound Cl- channels. Different cell populations resistant to...
Investigation of optoelectronic properties of benzotriazole and thiazole bearing conjugated polymers Ünay, Hakan; Çırpan, Ali; Department of Polymer Science and Technology (2019) This thesis deals with the design, synthesis and characterization of conjugated polymers P1 and P2 that have potential application in organic solar cell. Polymer design was accomplished by using band gap engineering method. According to that, benzodithiophene (BDT) and silafluorene were chosen as donor groups in P1 and P2 respectively. The acceptor parts were the same for both polymers including benzotriazole (BTZ) and thiazole group. According to electrochemical studies both polymers were having n-dopable ...
Predicting the effect of hydrophobicity surface on binding affinity of PCP-like compounds using machine learning methods Yoldaş, Mine; Alpaslan, Ferda Nur; Büyükbingöl, Erdem; Department of Computer Engineering (2011) This study aims to predict the binding affinity of the PCP-like compounds by means of molecular hydrophobicity. Molecular hydrophobicity is an important property which aff ects the binding affinity of molecules. The values of molecular hydrophobicity of molecules are obtained on three-dimensional coordinate system. Our aim is to reduce the number of points on the hydrophobicity surface of the molecules. This is modeled by using self organizing maps (SOM) and k-means clustering. The feature sets obtained fro...
Concise design and synthesis of pyridine-fused heterocycles via 6 pi- Azaelectrocyclization process of iminoalkyne derivatives Sendil, Kivilcim; Keskin, Selbi; Balcı, Metin (Elsevier BV, 2019-11-15) A concise and regioselective approach to the synthesis of pyridine-fused heterocycles and benzoxazepine derivatives was developed. Propargyl imines derived from aromatic aldehydes and propargyl amine underwent 6 pi-electrocyclization reactions at high temperatures in high yields to form pyridine-fused heterocycles. Application of the same methodology to aromatic imines having a hydroxyl group in the ortho position resulted in the formation of (benz)oxazepine derivatives. The formation mechanism of the produ...

Citation Formats

O. Hasturk, A. Sivas, B. Karasözen, U. Demirci, N. Hasırcı, and V. N. Hasırcı, “Quantification of Type, Timing, and Extent of Cell Body and Nucleus Deformations Caused by the Dimensions and Hydrophilicity of Square Prism Micropillars,” ADVANCED HEALTHCARE MATERIALS, pp. 2972–2982, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32435.