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Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding
Date
2004-07-21
Author
Persil Çetinkol, Özgül
JAIN, SS
HUD, NV
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Molecules that reversibly bind DNA and trigger the formation of non-Watson−Crick secondary structures would be useful in the design of dynamic DNA nanostructures and as potential leads for new therapeutic agents. We demonstrate that coralyne, a small crescent-shaped molecule, promotes the formation of a duplex secondary structure from homo-adenine oligonucleotides. AFM studies reveal that the staggered alignment of homo-adenine oligonucleotides upon coralyne binding produces polymers of micrometers in length, but only 2 nm in height. A DNA duplex was also studied that contained eight A·A mismatches between two flanking 7-bp Watson−Crick helices. CD spectra confirm that the multiple A·A mismatches of this duplex bind coralyne in manner similar to that of homo-adenine oligonucleotides. Furthermore, the melting temperature of this hybrid duplex increases by 13 °C upon coralyne binding. These observations illustrate that the helical structure of the homo-adenine−coralyne duplex is compatible with the B-form DNA helix.
Subject Keywords
Colloid and Surface Chemistry
,
Biochemistry
,
General Chemistry
,
Catalysis
URI
https://hdl.handle.net/11511/34728
Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
DOI
https://doi.org/10.1021/ja0492891
Collections
Department of Chemistry, Article
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Ö. Persil Çetinkol, S. JAIN, and N. HUD, “Assembly of an antiparallel homo-adenine DNA duplex by small-molecule binding,”
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
, pp. 8644–8645, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/34728.