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Integration of topological measures for eliminating non-specific interactions in protein interaction networks

2009-05-28
BAYIR, Murat Ali
GUNEY, Tacettin Dogacan
Can, Tolga
High-throughput protein interaction assays aim to provide a comprehensive list of interactions that govern the biological processes in a cell. These large-scale sets of interactions, represented as protein-protein interaction networks, are often analyzed by computational methods for detailed biological interpretation. However, as a result of the tradeoff between speed and accuracy, the interactions reported by high-throughput techniques occasionally include non-specific (i.e., false-positive) interactions. Unfortunately, many computational methods are sensitive to noise in protein interaction networks; and therefore they are not able to make biologically accurate inferences.