Determining the origin of synchronous multifocal bladder cancer by exome sequencing

Date

2015-11-09

Author

Acar, Omer
Ozkurt, Ezgi
Demir, Gulfem
Sarac, Hilal
ALKAN, CAN
Esen, Tarik
Somel, Mehmet
LACK, NATHAN

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Background: Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses. A potential cause of this uncertainty may be the small number of genetic mutations previously used to quantify the relationship between these tumours.

Subject Keywords

Multifocal bladder cancer, Next-generation sequencing, Population genetics, APOBEC deaminase

URI

https://hdl.handle.net/11511/35421

Collections

Department of Biology, Article