Determining the origin of synchronous multifocal bladder cancer by exome sequencing

Acar, Omer
Ozkurt, Ezgi
Demir, Gulfem
Sarac, Hilal
Esen, Tarik
Somel, Mehmet
Background: Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses. A potential cause of this uncertainty may be the small number of genetic mutations previously used to quantify the relationship between these tumours.


Investigation of the cellular mechanisims underlying the Carboxypeptidase E mutation
Kaşıkçı, Feride; Yanık, Tülin; Department of Biology (2014)
Carboxypeptidase E (CPE) is an enzyme expressed in both endocrine and neuroendocrine cells functioning as both an exopeptidase and a sorting receptor. Recently, it has been reported that CPE plays a role in preventing neuronal cell death in the CA3 hippocampus so as to maintain normal cognitive function in the adult brain. Studies on CPE-knockout mice showed total degeneration of neurons in the CA3 region of the hippocampus in adult mice 4 weeks of age and older. Additionally, increased CPE expression was i...
Investigating the malleability of RNA aptamers
İlgü, Müslüm; Lamm, Monica H.; Nilsen-Hamilton, Marit (Elsevier BV, 2013-09-15)
Aptamers are short, single-stranded nucleic acids with structures that frequently change upon ligand binding and are sensitive to the ionic environment. To achieve facile application of aptamers in controlling cellular activities, a better understanding is needed of aptamer ligand binding parameters, structures, intramolecular mobilities and how these structures adapt to different ionic environments with consequent effects on their ligand binding characteristics. Here we discuss the integration of biochemic...
Molecular investigation of ptz-induced epileptic activities in rat brain cell membranes and the effects of vigabatrin
Görgülü Türker, Sevgi; Severcan, Feride; Department of Biology (2009)
The epilepsies are a heterogenous group of symptom complexes, whose common features is the recurrence of seizures. There is no certain therapy for epilepsy. In order to promote new advances for the prevention of epilepsy the molecular mechanism of epileptic activities should be clarified. In the present study the goal is to obtain information for molecular mechanism of epilepsy. To achieve this, molecular alterations from pentylenetetrazol (PTZ)-induced epileptic activities on rat brain tissue and cell memb...
The effects of insertional mutations in comQ, comP, srfA, spo0H, spo0A and abrB genes on bacilysin biosynthesis in Bacillus subtilis
Karatas, AY; Cetin, S; Özcengiz, Gülay (Elsevier BV, 2003-04-15)
In Bacillus subtilis, two extracellular signaling peptides, ComX pheromone and CSF (competence and sporulation factor), stimulate the development of genetic competence and surfaction biosynthesis in response to high cell density (quorum sensing) by regulating the activity of transcription factor ComA. We recently showed that biosynthesis of dipeptide antibiotic bacilysin is linked to ComA and PhrC(CSF) in a Spo0K(Opp)-dependent manner by constructing phrC-, comA- and oppA-disrupted mutants of B. subtilis. I...
An investigation of microRNAs mapping to breast cancer related genomic gain and loss regions
Selcuklu, S. D.; Yakicier, M. C.; Erson Bensan, Ayşe Elif (Elsevier BV, 2009-02-01)
Various regions of amplification or loss are observed in breast tumors as a manifestation of genomic instability. To date, numerous oncogenes or tumor suppressors on some of these regions have been characterized. An increasing body of evidence suggests that such regions also harbor microRNA genes with crucial regulatory roles in cellular processes and disease mechanisms, including cancer. Here, we investigated 35 microRNAs localized to common genomic gain and/or loss regions in breast cancers. To examine am...
Citation Formats
O. Acar et al., “Determining the origin of synchronous multifocal bladder cancer by exome sequencing,” BMC CANCER, pp. 0–0, 2015, Accessed: 00, 2020. [Online]. Available: