Investigation and scale-up of hot-melt coating of pharmaceuticals in fluidized beds

Date

2011-03-10

Author

Külah, Görkem

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This study was performed to investigate and scale-up the hot-melt coating process in fluidized beds. A series of well-designed experiments was carried out in a pilot scale unit with 20 kg product capacity to investigate the effects of process variables on the efficiency of the coating of Cefuroxime Axetil with stearic acid. Results showed that the efficiency is at the highest when the fluidization air flow rate is adjusted by considering the changes in the amount of materials present in the unit as well as the changes in the terminal velocities of particles during the process.

Subject Keywords

General Chemical Engineering

URI

https://hdl.handle.net/11511/35797

Journal

POWDER TECHNOLOGY

DOI

https://doi.org/10.1016/j.powtec.2010.12.016

Collections

Department of Chemical Engineering, Article

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Citation Formats

G. Külah, “Investigation and scale-up of hot-melt coating of pharmaceuticals in fluidized beds,” POWDER TECHNOLOGY, pp. 175–184, 2011, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/35797.