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N-Substituted aziridine-2-phosphonic acids and their antibacterial activities
Date
2020-04-01
Author
Khan, Rehan
Doğan, Özdemir
Guven, Kiymet
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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N-substituted aziridine diethyl phosphonates were synthesized easily in two steps starting from vinyl phosphonate or acetyl phosphonate. The controlled mono hydrolysis without opening the aziridine ring under mild reaction conditions was achieved by alkaline solution of LiOH. The corresponding phosphoric acid lithium salt was desalted by the use of Amberlite IRC-50H(+) acting as an efficient and recyclable weakly acidic cation exchange promoter. Antimicrobial activity of the synthesized compounds was tested against E. coli ATCC 25922, Staphylococcus aureus (MRSA), Klebsiella pneumoniae NRLL B-4420, Acetobacter baumanii (wild type), Pseudomonas aeroginosa (ATCC 27853) and Enterobacter aerogenes NRLL B-3567. In general, all the compounds showed moderate antibacterial activity.
Subject Keywords
Organic Chemistry
URI
https://hdl.handle.net/11511/36529
Journal
ORGANIC COMMUNICATIONS
DOI
https://doi.org/10.25135/acg.oc.77.20.03.1594
Collections
Department of Chemistry, Article
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R. Khan, Ö. Doğan, and K. Guven, “N-Substituted aziridine-2-phosphonic acids and their antibacterial activities,”
ORGANIC COMMUNICATIONS
, pp. 51–56, 2020, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/36529.