Show/Hide Menu
Hide/Show Apps
anonymousUser
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Videos
Videos
Thesis submission
Thesis submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Contact us
Contact us
Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
Download
index.pdf
Date
2001-09-15
Author
Gursel, I
Gürsel, Mayda
Ishii, KJ
Klinman, DM
Metadata
Show full item record
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
Item Usage Stats
6
views
8
downloads
Cite This
Immunostimulatory CpG oligonucleotides (ODN) show promise as immune adjuvants, anti-allergens, and immunoprotective agents. Increasing the bioavailability and duration of action of CpG ODN should improve their therapeutic utility. Encapsulating ODN in sterically stabilized cationic liposomes provides protection from serum nucleases while facilitating uptake by B cells, dendritic cells, and macrophages. In a pathogen challenge model, sterically stabilized cationic liposomes encapsulation doubled the duration of CpG ODN-induced immune protection. In an immunization model, coencapsulation of CpG ODN with protein Ag (OVA) magnified the resultant Ag-specific IFN-gamma and IgG responses by 15- to 40-fold compared with Ag plus CpG ODN alone. These findings support the use of sterically stabilized cationic liposomes to significantly enhance the therapeutic efficacy of CpG ODN.
Subject Keywords
Immunology
URI
https://hdl.handle.net/11511/37248
Journal
JOURNAL OF IMMUNOLOGY
DOI
https://doi.org/10.4049/jimmunol.167.6.3324
Collections
Department of Biology, Article
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
I. Gursel, M. Gürsel, K. Ishii, and D. Klinman, “Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides,”
JOURNAL OF IMMUNOLOGY
, vol. 167, no. 6, pp. 3324–3328, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37248.