New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton

2010-04-01
Dengiz, Çağatay
OZCAN, Sevil
ŞAHİN, Ertan
Balci, METİN
We hereby report a new synthetic methodology for construction of the 1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one skeleton. 2-(2-Carboxyethyl)benzoic acid was converted into the corresponding bis(acyl azide). Curtius rearrangement of the diazide followed by reaction with alcohols provided diurethane derivatives. Ring-closure reaction of the diurethanes with base resulted in formation of the 1,3-benzodiazepin-2-one skeleton.

Citation Formats
Ç. Dengiz, S. OZCAN, E. ŞAHİN, and M. Balci, “New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton,” SYNTHESIS-STUTTGART, no. 8, pp. 1365–1370, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37255.