New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton

Date

2010-04-01

Author

Dengiz, Çağatay
ŞAHİN, Ertan
Balci, METİN

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We hereby report a new synthetic methodology for construction of the 1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one skeleton. 2-(2-Carboxyethyl)benzoic acid was converted into the corresponding bis(acyl azide). Curtius rearrangement of the diazide followed by reaction with alcohols provided diurethane derivatives. Ring-closure reaction of the diurethanes with base resulted in formation of the 1,3-benzodiazepin-2-one skeleton.

Subject Keywords

Organic Chemistry, Catalysis

URI

https://hdl.handle.net/11511/37255

Journal

SYNTHESIS-STUTTGART

DOI

https://doi.org/10.1055/s-0029-1218673

Collections

Department of Chemistry, Article

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Citation Formats

Ç. Dengiz, E. ŞAHİN, and M. Balci, “New Synthetic Methodology for Construction of the 1,3,4,5-Tetrahydro-2H-1,3-benzodiazepin-2-one Skeleton,” SYNTHESIS-STUTTGART, pp. 1365–1370, 2010, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/37255.